Hormone and Metabolic Research, Inhaltsverzeichnis Horm Metab Res 1983; 15(11): 523-526DOI: 10.1055/s-2007-1018778 © Georg Thieme Verlag, Stuttgart · New YorkDecreased Sensitivity of Platelets to Prostacyclin in Patients with Diabetes MellitusT. Akai1 , K. Naka1 , K. Okuda1 , T. Takemura2 , S. Fujii2 1Department of Laboratory Medicine, Osaka City University Medical School, Osaka, Japan 2Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Summary In order to ascertain the platelet sensitivity to prostacyclin (PGI2) in patients with diabetes mellitus, we determined the percentage inhibition of platelet aggregation and platelet ATP secretion following PGI2 addition in an in vitro system. The percentage inhibition of platelet aggregation caused by PGI2 in final concentration of 1.25, 2.5, or 5.0 ng/ml was significantly lower in diabetics than in healthy controls. That of platelet ATP secretion by 1.25 or 2.5 ng/ml of PGI2 was also significantly lower in diabetics. These data suggested that in patients with diabetes mellitus, the decreased sensitivity of platelets to PGI2 will bring about hypercoagulability and may become one of the risk factors of diabetic microangiopathy in cooperation with lowered vascular PGI2 generation. Key-Words: Diabetes Mellitus - Prostacyclin (PGI2) - Platelet Aggregation - Platelet ATP Secretion - Diabetic Microangiopathy PDF (292 kb)
