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Horm Metab Res 1981; 13(2): 95-98
DOI: 10.1055/s-2007-1019183
© Georg Thieme Verlag, Stuttgart · New York

Failure of Somatostatin and β-Endorphin to Affect Bovine Adrenal Cortex Cells In Vitro

F. Diel, J. Holz, N. Bethge
  • Abteilung Arbeitsmedizinische Toxikologie, Institut für Arbeitsphysiologie an der Universität Dortmund, Dortmund, Germany
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Publication History

1980

1980

Publication Date:
14 March 2008 (online)

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Summary

The main intention of this study was to examine the effect of cyclic somatostatin (SRIF) on bovine adrenal cell activity in vitro. β-Endorphin was applied in another course of experiments.

Basal aldosterone secretion when measured was found to be 0.86 ± 0.33 ng per 105 cells and 1.5 h incubation time in the glomerulosa cell fractions. Cortisol production was 1.6 ± 0.3 ng per 105 cells in the fasciculata/reticularis cell incubates respectively. No effect was observed when cyclic somatostatin (SRIF) was added to cell incubates of the bovine adrenal cortex. However, aldosterone secretion was increased 4.5-fold in the presence of 10-9M ACTH or 10-8M At II. Cortisol production was enhanced similarly after addition of 10-9M ACTH.

Increasing concentrations of β-endorphin had only a weak and non-significant effect on aldosterone production by the zona glomerulosa cell incubates.

Key-Words:

Somatostatin - β-Endorphin - ACTH - Adrenal Cortex Cells - Bovine