Subscribe to RSS
DOI: 10.1055/s-2007-1019183
Failure of Somatostatin and β-Endorphin to Affect Bovine Adrenal Cortex Cells In Vitro
Publication History
1980
1980
Publication Date:
14 March 2008 (online)

Summary
The main intention of this study was to examine the effect of cyclic somatostatin (SRIF) on bovine adrenal cell activity in vitro. β-Endorphin was applied in another course of experiments.
Basal aldosterone secretion when measured was found to be 0.86 ± 0.33 ng per 105 cells and 1.5 h incubation time in the glomerulosa cell fractions. Cortisol production was 1.6 ± 0.3 ng per 105 cells in the fasciculata/reticularis cell incubates respectively. No effect was observed when cyclic somatostatin (SRIF) was added to cell incubates of the bovine adrenal cortex. However, aldosterone secretion was increased 4.5-fold in the presence of 10-9M ACTH or 10-8M At II. Cortisol production was enhanced similarly after addition of 10-9M ACTH.
Increasing concentrations of β-endorphin had only a weak and non-significant effect on aldosterone production by the zona glomerulosa cell incubates.
Key-Words:
Somatostatin - β-Endorphin - ACTH - Adrenal Cortex Cells - Bovine