Fully synthetic human insulin (CGP 12′831) was compared to porcine insulin in identical
and non-identical formulation by intravenous insulin tolerance tests in 12 volunteers.
The half-lives of the three insulins tested did not differ (t 1/2: 5.5 ± 0.2 minutes),
though acid porcine insulin exhibited lower serum peak values. The hypoglycemic effects
of the three insulins were identical. Human insulin produced a significantly smaller
decrease in serum potassium (2p < 0.01). The secretion of serum C-peptide was less
inhibited by human insulin (2p < 0.05). The counter-regulatory hormonal response of
cortisol and growth hormone was lower after hypoglycemia induced by human insulin
(2p < 0.05).
It is suggested that the hormonal effects of hypoglycemia are modified by human insulin
and depend in part on the molecular structure of insulin.
Synthetic Human Insulin
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Insulin-Induced Hypoglycemia
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Growth Hormone
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C-Peptide
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Cortisol
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Counter-Regulatory Hormones
