A group of Yucatan miniature swine exhibiting impaired glucose tolerance (Kq = .91
± .04), were examined with respect to their portal and hepatic vein insulin levels
following a fasting intravenous glucose tolerance test. The majority of these animals
(9 of 11) were found to exhibit the expected portal vein insulin deficiency. This
deficiency was found to encompass all phases of the insulin response and was not limited
to the acute secretory phase. The remaining two animals were found to have normal
portal vein insulin concentrations while exhibiting reduced hepatic vein insulin levels,
and impaired glucose tolerance. An excessive rate of hepatic insulin extraction is
proposed to explain the etiology of the insulin deficiency and glucose intolerance
observed in these latter two animals.
Insulin
-
Glucose Tolerance
-
Liver
-
Pancreas
-
Miniature Swine
