Int J Sports Med 1994; 15(1): 32-35
DOI: 10.1055/s-2007-1021016

© Georg Thieme Verlag Stuttgart · New York

Anaphylatoxin C5a Production During Short-Term Submaximal Dynamic Exercise in Man

G. Camus1 , J. Duchateau5 , G. Deby-Dupont2 , 3 , J. Pincemail2 , C. Deby2 , A. Juchmès-Ferir4 , F. Feron, M. Lamy3
  • 1Research Associate, FNRS, Laboratory of Human Applied Physiology, ISEPK (B21)
  • 2Center for the Biochemistry of Oxygen
  • 3Department of Anesthesiology
  • 4Department of Clinical Biology, University of Liège, Center for the Biochemistry of Oxygen, Sart Tilman, Liège, Belgium
  • 5Department of Immunology, Hôpital Universitaire Saint-Pierre, Bruxelles
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Publication History

Publication Date:
14 March 2008 (online)


We studied the effects of short-term sub-maximal exercise on the plasma levels of myeloperoxidase ([MPO]) and C5a anaphylatoxin ([C5a]), taken as specific markers of polymorphonuclear neutrophil (PMN) and complement activation, respectively. Eleven young, healthy male volunteers were subjected to a constant-load concentric exercise on a cycle ergometer (20 min at 80% maximal oxygen uptake). Mean resting MPO and C5a concentrations were 437±113 and 0.47±0.21 ng/ml, respectively. During exercise, [MPO] and [C5a] increased significantly (p < 0.001) towards respective peak values of 649 ± 131 and 1.310.6 ng/ml. A rapid decrease of both [MPO] and [C5a] was observed during recovery. The similar time course of [MPO] and [C5a] changes and the highly significant relationship between these two variables (r = 0.651; p < 0.001) argues for the possible involvement of the complement anaphylatoxin C5a in the process of PMN degranulation. During exercise, the number of circulating PMN increased (+ 80%; p < 0.001) and remained practically unchanged up to 20 minutes of recovery. As [MPO] and PMN count were not significantly related (r = 0.2; p < 0.1), we concluded that the activation of PMN was independent of their mobilization.