Ultraschall Med 2007; 28(3): 307-312
DOI: 10.1055/s-2007-963222
Originalarbeit

© Georg Thieme Verlag KG Stuttgart · New York

Die Eignung der hochfrequenten Sonografie zur Diagnostik des DCIS

The Suitability of High-Resolution Ultrasound for the Detection of DCISH. Hille1 , M. Vetter2 , B. J. Hackelöer2
  • 1Praxis für Frauenheilkunde, Hamburg
  • 2Geburtshilfe, Asklepios Barmbek
Further Information

Publication History

eingereicht: 3.12.2006

angenommen: 4.5.2007

Publication Date:
22 June 2007 (online)

Zusammenfassung

Ziel: Darstellung der Wertigkeit der hochfrequenten Mammasonografie zur Diagnostik des DCIS. Material und Methoden: Literaturüberblick und Beschreibung der sonografischen Merkmale des DCIS mit Illustrationen. Ergebnisse: Die Sonografie kann heute insgesamt das DCIS in einer zur Mammografie vergleichbaren Größenordnung detektieren. Besondere Fähigkeiten der Sonografie zeigen sich bei mammografisch okkulten DCIS ohne Mikrokalk und DCIS in dichten bis sehr dichten Mammae. Der sonografischen Beurteilung der Drüsenarchitektur ganzer Lobi kommt neben der Detektion umschriebener Herdbefunde steigende Bedeutung zu. Schlussfolgerung: Die Sonografie stellt neben der Mammografie eine wichtige Methode in der Diagnostik des DCIS dar.

Abstract

Purpose: Presentation of the suitability of breast ultrasound for detecting DCIS of the breast. Materials and Methods: Review of literature on the topic and description of the sonographic features of DCIS illustrated by cases. Results: Breast ultrasound is currently capable of detecting DCIS with a comparable success rate to that of mammography. The advantages of sonography become obvious in cases of DCIS without microcalcifications and DCIS in dense or very dense breasts. The assessment of the sonographic architecture of the whole lobe, not just circumscribed lesions, is becoming increasingly important. Conclusion: Breast ultrasound represents an important tool for detecting DCIS in addition to mammography.

Literatur

  • 1 Radford D M, Philipps N HJ, Fair K L. et al . Allelic loss and the progression of breast cancer.  Cancer Res. 1995;  55 5180-5183
  • 2 Stratton M R, Collins N, Lakhani S R. et al . Loss of heterozygosity in ductal carcinoma in situ of the breast.  J Pathol. 1995;  175 195-201
  • 3 Hannemann J, Velds A, Halfwerk J BG. et al . Classification of ductal carcinoma in situ by gene expression profiling.  Breast Cancer Res. 2006;  8 R61; doi: 10.1186/brc1613
  • 4 Ernster V L, Barclay J, Kerlikowske K. et al . Incidence of and treatment for ductal carcinoma in situ of the breast.  JAMA. 1996;  275 913-918
  • 5 Ernster V L, Ballard-Barbasch R, William E B. et al . Detection of ductal carcinoma in situ in women undergoing screening mammography.  J Natl Cancer Inst. 2002;  94 1546-1554
  • 6 Barchielli A, Federico M, De Lisi V. et al . In situ breast cancer: incidence trend and organised screening programmes in Italy.  Eur J Cancer. 2005;  41 1045-1050
  • 7 Teboul M, Hallwell M. Atlas of ultrasound and ductal echography of the breast. London; Blackwell Science 1995
  • 8 Kolb T M, Lichy J, Newhouse J H. Occult Cancer in women with dense breasts: detection with screening US-diagnostic yield and tumor characteristics.  Radiology. 1998;  207 191-199
  • 9 Buchberger W, DeKoekkoek-Doll P, Springer P. et al . Incidental findings on sonography of the breast: clinical significance and diagnostic workup.  AJR. 1999;  173 921-927
  • 10 Kaplan S S. Clinical utility of bilateral whole-breast US in the evaluation of women with dense breast tissue.  Radiology. 2001;  221 641-649
  • 11 Schoonjans J M, Brem F R. Sonographic appearance of ductal carcinoma in situ diagnosed with ultrasonographically guided large core needle biopsy.  J Ultrasound Med. 2000;  19 449-457
  • 12 Moon W K, Myung J S, Lee Y J. et al . US of Ducal Carcinoma In Situ.  RadioGraphics. 2002;  22 269-281
  • 13 Stavros A T. Ultrasound of Ductal Carcinoma in Situ. Silverstein ML Ductal Carcinoma in Situ of the Breast Philadelphia. Lippincott; Williams & Wilkins 2002 Second edition: 129-169
  • 14 Stavros A T. Malignant solid breast nodules: specific types. Stavros AT Breast Ultrasound Philadelphia: Lippincott; Williams & Wilkins 2004: 598-612
  • 15 Chen S C, Cheung Y C, Lo Y F. et al . Sonographic differentiation of invasive and intraductal carcinomas of the breast.  BJR. 2003;  76 600-604
  • 16 Yang W T, Tse G MK. Sonographic, mammographic, and histopathologic correlation of symptomatic ductal carcinoma in situ.  AJR. 2004;  182 101-110
  • 17 Moon W K, Dong-Yang N, Jung-Gi I. Multifocal, multicentric, and contralateral breast cancers: bilateral whole-breast US in the preoperative evaluation of patients.  Radiology. 2002;  224 596-576
  • 18 LaTrenta L R, Menell J H, Morris E A. et al . Breast lesions detected with MR imaging: utility and histopathologic importance of identification with US.  Radiology. 2003;  227 856-861
  • 19 Berg W A, Gutierrez L, Nessaiver M S. et al . Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer.  Radiology. 2004;  233 830-849
  • 20 Grunert J H, Hille H. Mammasonographie und Mammographie in der dezentralen Brustkrebsdiagnostik.  GebFra. 2006;  66 670-673
  • 21 Sardanelli F, Giuseppetti G M, Panizza P. et al . Sensitivity of MRI versus mammography for detecting foci of multifocal multicentric breast cancer in fatty and dense breasts using the whole-breast pathologic examination as a gold standard.  AJR. 2004;  183 1149-1157
  • 22 Bluemke D A, Gatsonis C A, Chen M H. et al . Magnetic resonance imaging prior to biopsy.  JAMA. 2004;  292 2735-2742
  • 23 Menell J H, Morris E A, Dershaw D D. et al . Determination of the presence and extent of pure ductal carcinoma in situ by mammography and magnetic resonance imaging.  Breast J. 2005;  11 382-390
  • 24 Leucht W. Lehratlas der Mammasonographie. Stuttgart; Thieme 1989
  • 25 Ultraschallvereinbarung der KBV (Anlage 3 BMV-Ä/EKV) vom 10.2.1993. www.kbv.de/rechtsquellen
  • 26 Marquet K L, Wolter M, Handt S. et al . Mammasonographische Dignitätskriterien unter besonderer Berücksichtigung der Tumorgröße.  Ultraschall in Med. 2002;  23 383-387
  • 27 Schulz-Wendtland R, Bock K, Aichinger U. et al . Mamma-Sonographie mit 7,5MHz versus 13 MHz: Ist eine Verbesserung der diagnostischen Sicherheit im Rahmen der komplementären Mammadiagnostik möglich?.  Ultraschall in Med. 2005;  26 209-215
  • 28 Morgan M P, Cooke M M, Mc Carthy G M. Microcalcifications associated with breast cancer: an epiphenomenon or biologically significant feature of selected tumors?.  J Mammmary Gland Biol Neoplasia. 2005;  10 181-187
  • 29 Seymour H R, Cooke J, Given-Wilson R. The significance of spontaneous resolution of breast calcification.  BJR. 1999;  72 3-8
  • 30 Barreau B, Mascarel de I, Feuga C. et al . Mammography of ductal carcinoma in situ of the breast: review of 909 cases with radiographic-pathologic correlations.  Eur J Radiol. 2005;  54 55-61
  • 31 Mulz D, Egger H, Knupfer A. et al . Mikrokalk im Mammogramm und Darstellungsmöglichkeit im Ultraschall.  GebFra. 1981;  41 255-258
  • 32 Kasumi F, Tanaka H. Detection of microcalcifications in breast carcinoma by ultrasound. Jellins J, Kobayashi T Ultrasound examination of the breast New York; John Wiley &Sons 1983: 89-97
  • 33 Harper P, Kelly-Fry E. Ultrasound visualisation of the breast in symptomatic patients.  Radiology. 1980;  137 465-469
  • 34 Lambie R W, Hodgdan D, Herman E M. et al . Sonomammographic manifestations of mammographically detectable breast microcalcifications.  J Ultrasound Med. 1983;  2 509-514
  • 35 Potterton A J, Peakman D J, Young J R. Ultrasound demonstration of small breast cancers detected by mammographic screening.  Clin Radiol. 1994;  49 808-813
  • 36 Dudwiesus H. Persönliche Mitteilung,. Solingen; GE Healthcare
  • 37 Kasumi F. Can microcalcifications located within breast carcinomas be detected by ultrasound imaging?.  Ultrasound Med Biol. 1988;  14 Suppl 1 175-182
  • 38 Anderson M E, Soo M S, Bentley R C. et al . The detection of breast microcalcifications with medical ultrasound.  J Acoust Soc Am. 1997;  101 29-39
  • 39 Yang W T, Suen M, Ahuja A. et al . In vivo demonstration of microcalcifications in breast cancer using high resolution ultrasound.  BJR. 1997;  70 685-690
  • 40 Moon W K, Im J G, Koh Y H. et al . US of mammographically detected clustered microcalcifications.  Radiology. 2000;  217 849-854
  • 41 Gufler H, Buitrago-Tellez C H, Madjar H. et al . Ultrasound demonstration of mammographically detected microcalcifications.  Acta Radiol. 2000;  41 217-221
  • 42 Hashimoto B E, Kramer D J, Picozzi V J. High detection rate of breast ductal carcinoma in situ calcifications on mammographically directed high-resolution sonography.  J Ultrasound Med. 2001;  20 501-508
  • 43 Cheung Y C, Wan Y L, Chen S C. et al . Sonographic evaluation of mammographically detected microcalcifications without a mass prior to stereotactic core needle biopsy.  J Clin Ultrasound. 2002;  30 323-331
  • 44 Soo M S, Baker J A, Rosen E L. Sonographic detection and sonographically guided biopsy of breast microcalcifications.  AJR. 2003;  180 941-948
  • 45 Marini C, Traino C, Cilotti A. et al . Differentiation of benign and malignant breast microcalcifications: mammography versus mammography-sonography combination.  Radiol Med. 2003;  105 17-26
  • 46 Nagashima T, Hashimoto H, Oshida K. et al . Ultrasound demonstration of mammographically detected microcalcifications in patients with ductal carcinoma in situ of the breast.  Breast Cancer. 2005;  12 216-220
  • 47 Tot T. DCIS, cytokeratins, and the theory of the sick lobe.  Virchows Arch. 2005;  447 1-8
  • 48 Madjar H, Ohlinger R, Mundinger A. et al . BI-RADS analoge DEGUM Kriterien von Ultraschallbefunden der Brust - Konsensus des Arbeitskreises Mammasonographie der DEGUM.  Ultraschall in Med. 2006;  27 374-379
  • 49 Ohlinger R, Klein G M, Köhler G. Ultrasound of the breast - value of sonographic criteria for the differential diagnosis of solid lesions.  Ultraschall in Med. 2004;  25 48-53

Dr. Heino Hille

Praxis für Frauenheilkunde

Lappenbergsallee 50

20257 Hamburg

Phone: ++49/40/40 33 40

Fax: ++49/40/49 43 36

Email: heino.hille@t-online.de

    >