Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000088.xml
TumorDiagnostik & Therapie 2007; 28(4): 195-199
DOI: 10.1055/s-2007-963398
DOI: 10.1055/s-2007-963398
Thieme Onkologie aktuell
© Georg Thieme Verlag KG Stuttgart · New York
Palliative Therapie des Pankreaskarzinoms
Palliative treatment of pancreatic cancerFurther Information
Publication History
eingereicht: 27.11.2006
angenommen: 20.12.2006
Publication Date:
10 August 2007 (online)

Schlüsselwörter
Pankreaskarzinom - Chemotherapie - Gemcitabin
Key words
pancreatic cancer - chemotherapy - gemcitabine
Literatur
- 1
Abou-Alfa G K, Letourneau R, Harker G, Modiano M, Hurwitz H, Tchekmedyian N S, Feit K, Ackerman J, De Jager R L, Eckhardt S G, O’Reilly E M.
Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone
in untreated advanced pancreatic cancer.
J Clin Oncol.
2006;
24
4441-4447
Reference Ris Wihthout Link
- 2
Berlin J D, Catalano P, Thomas J P, Kugler J W, Haller D G, Benson A B.
Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine
alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology
Group Trial E2297.
J Clin Oncol.
2002;
20
3270-3275
Reference Ris Wihthout Link
- 3
Bramhall S R, Rosemurgy A, Brown P D, Bowry C, Buckels J A.
Marimastat as first-line therapy for patients with unresectable pancreatic cancer:
a randomized trial.
J Clin Oncol.
2001;
19
3447-3455
Reference Ris Wihthout Link
- 4
Burris H A 3 rd, Moore M J, Andersen J, Green M R, Rothenberg M L, Modiano M R, Cripps M C, Portenoy R K, Storniolo A M, Tarassoff P, Nelson R, Dorr F A, Stephens C D, Von Hoff D D.
Improvements in survival and clinical benefit with gemcitabine as first-line therapy
for patients with advanced pancreas cancer: a randomized trial.
J Clin Oncol.
1997;
15
2403-2413
Reference Ris Wihthout Link
- 5
Glimelius B, Hoffman K, Sjoden P O, Jacobsson G, Sellstrom H, Enander L K, Linne T, Svensson C.
Chemotherapy improves survival and quality of life in advanced pancreatic and biliary
cancer.
Ann Oncol.
1996;
7
593-600
Reference Ris Wihthout Link
- 6
Heinemann V, Quietzsch D, Gieseler F, Gonnermann M, Schonekas H, Rost A, Neuhaus H, Haag C, Clemens M, Heinrich B, Vehling-Kaiser U, Fuchs M, Fleckenstein D, Gesierich W, Uthgenannt D, Einsele H, Holstege A, Hinke A, Schalhorn A, Wilkowski R.
Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine
alone in advanced pancreatic cancer.
J Clin Oncol.
2006;
24
3946-3952
Reference Ris Wihthout Link
- 7
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun M J.
Cancer statistics, 2006.
CA Cancer J Clin.
2006;
56
106-130
Reference Ris Wihthout Link
- 8
Larsson S C, Permert J, Hakansson N, Naslund I, Bergkvist L, Wolk A.
Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to
the risk of pancreatic cancer in two Swedish population-based cohorts.
Br J Cancer.
2005;
93
1310-1315
Reference Ris Wihthout Link
- 9
Louvet C, Labianca R, Hammel P, Lledo G, Zampino M G, Andre T, Zaniboni A, Ducreux M, Aitini E, Taieb J, Faroux R, Lepere C, Gramont de A.
Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally
advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III
trial.
J Clin Oncol.
2005;
23
3509-3516
Reference Ris Wihthout Link
- 10
Lutz M P, Koniger M, Muche R, Ellenrieder V, Steinkamp M, Adler G, Gress T M.
A phase II study of weekly 24-h infusion of high-dose 5-fluorouracil in advanced pancreatic
cancer.
Z Gastroenterol.
1999;
37
993-997
Reference Ris Wihthout Link
- 11
Moertel C G, Frytak S, Hahn R G, O’Connell M J, Reitemeier R J, Rubin J, Schutt A J, Weiland L H, Childs D S, Holbrook M A, Lavin P T, Livstone E, Spiro H, Knowlton A, Kalser M, Barkin J, Lessner H, Mann-Kaplan R, Ramming K, Douglas H O, Thomas P, Nave H, Bateman J, Lokich J, Brooks J, Chaffey J, Corson J M, Zamcheck N, Novak J W.
Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high
dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil),
and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group.
Cancer.
1981;
48
1705-1710
Reference Ris Wihthout Link
- 12
Oettle H, Richards D, Ramanathan R K, Laethem J L, Peeters van M, Fuchs M, Zimmermann A, John W, Von Hoff D, Arning M, Kindler H L.
A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with
unresectable or metastatic pancreatic cancer.
Ann Oncol.
2005;
16
1639-1645
Reference Ris Wihthout Link
- 13
Petty R D, Nicolson M C, Skaria S, Sinclair T S, Samuel L M, Koruth M.
A phase II study of mitomycin C, cisplatin and protracted infusional 5-fluorouracil
in advanced pancreatic carcinoma: efficacy and low toxicity.
Ann Oncol.
2003;
14
1100-1105
Reference Ris Wihthout Link
- 14
Reni M, Cordio S, Milandri C, Passoni P, Bonetto E, Oliani C, Luppi G, Nicoletti R, Galli L, Bordonaro R, Passardi A, Zerbi A, Balzano G, Aldrighetti L, Staudacher C, Villa E, Di Carlo V.
Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced
pancreatic cancer: a randomised controlled multicentre phase III trial.
Lancet Oncol.
2005;
6
369-376
Reference Ris Wihthout Link
- 15
Rocha Lima C M, Green M R, Rotche R, Miller W H, Jeffrey G M, Cisar L A, Morganti A, Orlando N, Gruia G, Miller L L.
Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine
monotherapy in patients with locally advanced or metastatic pancreatic cancer despite
increased tumor response rate.
J Clin Oncol.
2004;
22
3776-3783
Reference Ris Wihthout Link
- 16 Statistisches Bundesamt .Krebs in Deutschland. Häufigkeit und Trends. Saarbrücken 2002
Reference Ris Wihthout Link
- 17
Steinberger M, Beyer A.
Tumorschmerzen Der konkrete Fall, Diagnostik und Therapie.
Dtsch med Wochenschr.
2005;
130
1449-1456
Reference Ris Wihthout Link
- 18
Tempero M, Plunkett W, Ruiz Van Haperen V, Hainsworth J, Hochster H, Lenzi R, Abbruzzese J.
Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion
and fixed dose rate infusion in patients with pancreatic adenocarcinoma.
J Clin Oncol.
2003;
21
3402-3408
Reference Ris Wihthout Link
- 19
Tsavaris N, Kosmas C, Skopelitis H, Gouveris P, Kopterides P, Loukeris D, Sigala F, Zorbala-Sypsa A, Felekouras E, Papalambros E.
Second-line treatment with oxaliplatin, leucovorin and 5-fluorouracil in gemcitabine-pretreated
advanced pancreatic cancer: A phase II study.
Invest New Drugs.
2005;
23
369-375
Reference Ris Wihthout Link
- 20
Ulrich-Pur H, Raderer M, Verena Kornek G, Schull B, Schmid K, Haider K, Kwasny W, Depisch D, Schneeweiss B, Lang F, Scheithauer W.
Irinotecan plus raltitrexed vs raltitrexed alone in patients with gemcitabine-pretreated
advanced pancreatic adenocarcinoma.
Br J Cancer.
2003;
88
1180-1184
Reference Ris Wihthout Link
- 21
Van Cutsem E, Velde van de H, Karasek P, Oettle H, Vervenne W L, Szawlowski A, Schoffski P, Post S, Verslype C, Neumann H, Safran H, Humblet Y, Perez Ruixo J, Ma Y, Von Hoff D.
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo
in advanced pancreatic cancer.
J Clin Oncol.
2004;
22
1430-1438
Reference Ris Wihthout Link
- 22
Xiong H Q, Rosenberg A, LoBuglio A, Schmidt W, Wolff R A, Deutsch J, Needle M, Abbruzzese J L.
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in
combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II
Trial.
J Clin Oncol.
2004;
22
2610-2616
Reference Ris Wihthout Link
- 23
Yip D, Karapetis C, Strickland A, Steer C B, Goldstein D.
Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer.
Cochrane Database Syst Rev.
2006;
3
CD002093
Reference Ris Wihthout Link
Professor Dr. Thomas Seufferlein
Abteilung Innere Medizin I
Universitätsklinikum Ulm
Robert Koch-Straße 8
89081 Ulm
Phone: 0731/5004-4508
Fax: 0731/5004-4502
Email: thomas.seufferlein@uniklinik-ulm.de
