Zusammenfassung
Die Prävalenz von Reizdarmsyndrom (RDS) hat in den letzten 50 Jahren in den Ländern
mit westlichen Verzehrsgewohnheiten zugenommen, 20 - 65 % der Patienten mit Reizdarmsyndrom
sehen einen Zusammenhang zwischen Nahrungsbestandteilen und der Beschwerdesymptomatik.
Die Daten zu Eliminationsdiäten und Provokationsversuchen sind jedoch widersprüchlich.
Obwohl es Untersuchungen gibt, dass Ballaststoffe bei einigen Reizdarmpatienten helfen
können, gibt es in der Literatur keine einheitlichen diätetischen Empfehlungen. Einige
Studien belegen, dass Probiotika zu einer Minderung der Symptome beitragen können.
Trotz verschiedener Arbeiten, die sich mit der Thematik beschäftigen, erscheint es
schwierig, Ernährungsempfehlungen für Reizdarmpatienten zu formulieren; jedoch kann
eine Ernährungsberatung durchaus wertvoll für die Patienten sein. Weitere prospektive
Studien sind erforderlich, um den Einfluss von diätetischen Faktoren und Probiotika
in diesem Zusammenhang zu evaluieren.
Abstract
The prevalence of irritable bowel syndrome (IBS) has increased over the last 50 years
in countries where a Western-style diet has been prominent or introduced and 20 -
65 % of patients with irritable bowel syndrome (IBS) attribute their symptoms to something
in food that activates an abnormal response. However, data from dietary elimination
and re-challenge studies are inconclusive. Although investigations have shown that
bran may be helpful in some patients, a complete review of the literature does not
reveal conclusive evidence that a high fibre diet therapy is effective in IBS. From
the limited reports on probiotics, there appears to be a trend to decreasing symptoms.
Despite numerous reviews on this subject, it is very difficult to give general dietary
advice to IBS patients, but dietary experts may have a positive role in managing such
patients. It is clear that much more prospective research is needed to study both
dietary factors and probiotics in these areas.
Schlüsselwörter
Reizdarmsyndrom - Ernährungstherapie - Fruktosemalabsorption - Laktoseintoleranz -
Diät - Prä-/Probiotika - Gluten - Pfefferminzöl
Key words
irritable bowel syndrome - nutrition therapy - fructose malabsorption - lactose malabsorption
- diet - pre-/probiotics - gluten - peppermint oil
Literatur
- 1
Adam B, Liebregts T, Holtmann G.
Das Reizdarmsyndrom.
Dtsch Med Wochenschr.
2005;
130
399-401
- 2
Aller R, de Luis D A, Izaola O. et al .
Efffects of a high-fiber diet on symptoms of irritable bowel syndrome : a randomized
clinical trial.
Nutrition.
2004;
20
735-737
- 3
Alpers D H.
Diet and irritable bowel syndrome.
Curr Opin Gastroenterol.
2006;
22
136-139
- 4
Arffmann S, Andersen J R, Hegnhoj J. et al .
The effect of coarse wheat bran in the irritable bowel syndrome: a double blind crossover
study.
Scand J Gastroenterol.
1985;
20
295-298
- 5
Anderson D E, Nygren A.
Four cases of long-standing diarrhea and colic pains cured by fructose-free diet -
a pathogenetic discussion.
Acta Med Scand.
1978;
203
87-92
- 6
Arthurs Y, Fielding J F.
Double blind trial of ispaghula poloxamer in irritable bowel syndrome.
J Assoc Physicians India.
1984;
12
1041-1044
- 7
Au A, Gupta A, Schembri P. et al .
Rapid insertion of GLUT2 into the rat jejunal brush-border membrane promoted by glucagons-like
peptide 2.
Biochem J.
2002;
367
247-254
- 8
Balsari A, Ceccarelli A, Dubin F. et al .
The faecal microbial population in the irritable bowel syindrome.
Microbiologica.
1982;
5
185-194
- 9
Barbara G, Stanghellini V, Brandi G. et al .
Interactions between commensal bacteria and gut sensorimotor function in health and
disease.
Am J Gastroenterol.
2005;
100
2560-2568
- 10
Barbara G, Stanghellini V, De Giorgio R. et al .
Activated mast cells in proximity to colonic nerves correlate with abdominal pain
in irritable bowel sindrome.
Gastroenterology.
2004;
126
693-702
- 11
Bausserman M, Michail S.
The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind
randomized control trial.
J Pediatr.
2005;
147
197-201
- 12
Bergonzelli G E, Blum S, Brüssow H. et al .
Probiotics as a treatment strategy for gastrointestinal diseases?.
Digestion.
2005;
72
57-68
- 13 Böhles H, Bargon J, Stein J. Ernährungstherapie von angeborenen Stoffwechsel- und
Speichererkrankungen. Stein J, Jauch KW Praxishandbuch klinische Ernährung und Infusionstherapie
Springer 2003: 652-676
- 14
Bohmer C JM, Tuynman H.
The clinical relevance of lactose malabsorption in irritable bowel syndrome.
Eur J Gastroenterol Hepatol.
1996;
8
1013-1016
- 15
Born P, Zech J, Lehn H. et al .
Colonic bacterial activity determines the symptoms in people with fructose-malabsorption.
Hepatogastroenterology.
1995;
42
778-785
- 16
Brigidi P, Vitali B, Swennen E. et al .
Effects of probiotic administration upon the composition and enzymatic activity of
human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea.
Res Microbiol.
2001;
152
735-741
- 17
Caldarella P, Milano A, Laterza F. et al .
Visceral sensitivity and symptoms in patients with constipation- or diarrea-predominant
irritable bowel sindrome (IBS): effect of a low-fat intraduodenal infusion.
Am J Gastroenterol.
2005;
100
383-389
- 18
Caldarella M P, Azpiroz F, Malagelada J R.
Selective effects of nutrients on gut sensitivity and reflexes.
Gut.
2006; [Epub ahead of print];
- 19
Camilleri M.
Management of the irritable bowel syndrome.
Gastroenterology.
2001;
120
652-668
- 20
Camilleri M.
Probiotics and irritable bowel syndrome: rationale, putative mechanisms, and evidence
of clinical efficacy.
J Clin Gastroenterol.
2006;
40
264-269
- 21
Cann P A, Read N W, Holdsworth C D.
What is the benefit of coarse wheat bran in patients with irritable bowel syndrome?.
Gut.
1984;
25
168-173
- 22
Castello A, Guma A, Sevilla L. et al .
Regulation of GLUT5 gene expression in rat intestinal mucosa: regional distribution,
circadian rhythm, perinatal development an effect of diabetes.
Biochem J.
1995;
309
271-277
- 23
Choi Y K, Johlin F C, Summers R W. et al .
Fructose intolerance: An under-recognized problem.
Am J Gastroenterol.
2003;
98
1348-1353
- 24
Cook I J, Irvine E J, Campbell D. et al .
Effect of dietary fiber on symptoms and rectosigmoid motility in patients with irritable
bowel syndrome: a controlles crossover study.
Gastroenterology.
1990;
98
66-72
- 25
Cummings J H, Macfarlane G T.
Gastrointestinal effects of prebiotics.
Br J Nutr.
2002;
87 (Suppl 2)
S145-S151
- 26
Dapoigny M, Stockbrugger R W, Azpiroz F. et al .
Role of alimentation in irritable bowel syndrome.
Digestion.
2003;
67
225-233
- 27
Dainese R, Galliani E A, DeLazzari F. et al .
Discrepancies between reported food intolerance and sensitization test findings in
irritable bowel syndrome patients.
Am J Gastroenterol.
1999;
94
1892-1897
- 28
De Baptista G.
Nutrients and dyspepsia: paradigms and reality.
Curr Opin Nutr Metab Care.
2005;
8
562-567
- 29
Dear K L, Elia M, Hunter J O.
Do interventions which reduce colonic bacterial fermentation improve symptoms of irritable
bowel syndrome?.
Dig Dis Sci.
2005;
50
758-766
- 30 Dingermann T, Loew D. Magen-Darm-Erkrankungen. Dingermann T, Loew D Phytopharmakologie
- Experimentelle und klinische Pharmakologie pflanzlicher Arzneimittel Stuttgart;
Wissenschaftliche Verlagsgesellschaft mbH 2003: 204-213
- 31
Drossman D A, Camilieri M, Mayer E A. et al .
AGA Technical review on irritable bowel syndrome.
Gastroenterology.
2002;
123
2108-2131
- 32
Drossman D A.
The functional gastrointestinal disorders an the Rome III process.
Gastroenterology.
2006;
130
1377-1390
- 33
Dyer J, Wood I S, Palejwala A. et al .
Expression of monosaccharide transporters in intestine of diabetic humans.
Am J Physiol.
2002;
282
G241-G248
- 34
Enck P, Kremer A, Kuhlbusch R. et al .
Prevalence of lactose malabsorption among patients with functional bowel disorders.
Z Gastroenterol.
1990;
28
239-234
- 35
Fernandez-Banares F, Esteve-Pardo M, Leon de R. et al .
Sugar malabsorption in functional bowel disease: clinical implications.
Am J Gastroenterol.
1993;
88
2044-2050
- 36
Floch M H.
Use of Diet and Probiotic Therapy in the irritable bowel syndrome. Analysis of the
literature.
J Clin Gastroenterol.
2005;
39
S243-S246
- 37
Fowlie S, Eastwood M, Prescott R.
Irritable bowel syndrome: assessment of psychological disturbance and its influence
on the response to fibre supplementation.
J Psychosom Res.
1992;
36
175-180
- 38
Francis C Y, Whorwell P J.
Bran and irritable bowel syndrome: time for reappraisal.
Lancet.
1994;
344
39-40
- 39
Freise J, Köhler S.
Peppermint oil-caraway oil fixed combination in non-ulcer dyspepsia - comparison of
the effects of enteric preparations.
Pharmazie.
1999;
54
210-215
- 40
Gade J, Thorn P.
Paraghurt for patients with irritable bowel syndrome. A controlled clinical investigation
from general practice.
Scand J Prim Health Care.
1989;
7
23-26
- 41
Garcia-Herrera J, Navarro M A, Marca M C. et al .
The effect of tumor necrosis factor-alpha on D-fructose intestinal transport in rabbits.
Cytokine.
2004;
25
21-30
- 42
Gibson P R, Shepherd S J.
Personal view: food for thought - western lifestyle and susceptibility to crohn’s
disease. The FODMAP hypothesis.
Aliment Pharmacol Ther.
2005;
21
1399-1409
- 43
Gibson P R, Newnham E, Barrett J S. et al .
Review article: fructose malabsorption and the bigger picture.
Aliment Pharmacol Ther.
2006;
25
349-363
- 44
Goldstein R, Braverman D, Stankiewicz H.
Carbohydrate malabsorption and the effect of dietary restriction on symptoms of irritable
bowel syndrome and functional bowel complaints.
Isr Med Assoc J.
2000;
2
583-587
- 45
Golecha A C, Chadda V S, Chadda S. et al .
Role of ispaghula husk in the management of irritable bowel syndrome (a randomized
double blind crossover Study).
J Assoc Physicians India.
1982;
30
353-355
- 46
Gouyon F, Caillaud L, Carriere V. et al .
Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption:
a study in GLUT2-null mice.
J Physiol.
2003;
552
823-832
- 47
Grigoleit H G, Grigoleit P.
Peppermint oil in irritable bowel syndrome.
Phytomedicine.
2005;
12
601-606
- 48
Grigoleit H G, Grigoleit P.
Gastrointestinal clinical pharmacology of peppermint oil.
Phytomedicine.
2005;
12
607-612
- 49
Halpern G M, Prindiville T, Blankenburg M. et al .
Treatment of irritable bowel syndrome with Lacteol Fort: a randomized, double-blind,
cross-over trial.
Am J Gastroenterol.
1996;
91
1579-1585
- 50
Hoekstra J H, van Kempen A A, Bijl S B. et al .
Fructose breath hydrogen tests.
Arch Dis Child.
1993;
68
136-138
- 51
Hoekstra J H, Aker J H.
Facilitating effect of amino acids on fructose and sorbitol absorption in children.
J Pediatr Gastroenterol Nutr.
1996;
23
118-124
- 52
Holtmann van den G, Gschossmann J M, Buenger L.
Effects of a fixed peppermint oil caraway oil combination (PCC) on symptoms and quality
of life in functional dyspepsia.
Gastroenterology.
2000;
120
(Suppl) 36
- 53
Holtmann G.
IBS: a syndrome or many diseases?.
Best Pract Res Clin Gastroenterol.
2004;
18 (Suppl)
91-97
- 54
Holtmeier W.
Diagnosis of celiac disease.
Z Gastroenterol.
2005;
43
1243-1252
- 55
Hotz J, Enck P, Goebell H. et al .
: Konsensusbericht: Reizdarmsyndrom-Definition, Diagnosesicherung, Pathophysiologie
und Therapiemöglichkeiten. Konsensus der Deutschen Gesellschaft für Verdauungs- und
Stoffwechselkrankheiten.
Z Gastroenterol.
1999;
37
685-700
- 56
Hussain Z, Quigley E M.
Systematic review: Complementary and alternative medicine in the irritable bowel syndrome.
Aliment Pharmacol Ther.
2006;
23
465-471
- 57
Jain N K, Patel V P, Pitchumoni C S.
Sorbitol intolerance in adults. Prevalence and pathogenesis on two continents.
J Clin Gastroenterol.
1987;
9
317-319
- 58
Jalihal A, Kurian G.
Ispaghula therapy in irritable bowel syndrome: improvement in overall well being related
to reduction in bowel dissatisfaction.
J Gastroenterol Hepatol.
1990;
5
507-513
- 59
Johlin F C, Panther M, Kraft N.
A fructose restricted diet and dietary counselling in patients with dietary fructose
intolerance demonstrates significant reduction in symptoms and an improvement in quality
of life proportionate to the amount of fructose eliminated.
Gastroenterology.
2001;
120
A1374 (Abstract)
- 60
Jones V A, McLaughlan P, Shorthouse M. et al .
Food intolerance: a major factor in the pathogenesis of irritable bowel syndrome.
Lancet.
1982;
20 (2)
1115-1117
- 61
Jun D W, Lee O Y, Yoon L J. et al .
Food intolerance and skin prick test in treated and untreated irritable bowel syndrome.
World J Gastroenterol.
2006;
21
2382-2387
- 62
Kajander K, Korpela R.
Clinical studies on alleviating the symptoms of irritable bowel syndrome.
Asia Pac J Clin Nutr.
2006;
15
576-580
- 63
Karamanolis G, Tack J.
Nutrition and motility disorders.
Best Pract Res Clin Gastroenterol.
2006;
20
485-505
- 64
Keller J, Franke A, Storr M. et al .
Clinically relevant breath tests in gastroenterological diagnostics - recommendations
of the German Society for Neurogastroenterology and Motility as well as the German
Society for Digestive and Metabolic Diseases.
Z Gastroenterol.
2005;
43
1071-1090
- 65
Kellett G L, Brot-Laroche E.
Apical GLUT2. A major pathway of intestinal sugar absorption.
Diabetes.
2005;
54
3056-3062
- 66
Kim H J, VazquezRoque M I, Camilleri M. et al .
A randomized controlled trial of a probiotic combination VSL#3 and placebo in irritable
bowel sindrome with bloating.
Neurogastroenterol Motil.
2005;
17
687-696
- 67
Kishi K, Tanaka T, Igawa M. et al .
Sucrase-isomaltase and hexose transporter gene expressions are coordinately enhanced
by dietary fructose in rat jejunum.
J Nutr.
1999;
129
953-956
- 68
Klauser A G, Volerholzer W A, Schindlbeck N E. et al .
Functional diagnosic work-up in patients with irritable bowel syndrome.
Z Gastroenterol.
1996;
34
273-278
- 69
Klein-Tebbe J, Lepp U, Niggemann B. et al .
Nahrungsmittelallergie und -unverträglichkeit: Bewährte statt nicht evaluierte Diagnostik.
Deutsches Ärzteblatt.
2005;
27
A1965-A1969
- 70
Kneepkens C M, Vonk R J, Fernandes J.
Incomplete intestinal absorption of fructose.
Arch Dis Child.
1984;
59
735-738
- 71
Koebnick C, Wagner I, Leitzmann P. et al .
Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal
symptoms in patients with chronic constipation.
Can J Gastroenterol.
2003;
17
655-659
- 72
Krammer H J, Schlieger F, Harder H. et al .
Probiotics as therapeutic agents in irritable bowel syndrome.
Z Gastroenterol.
2005;
43
467-471
- 73
Krammer H J, Kamper H, Bunau von R. et al .
Probiotic drug therapy with E. coli strain Nissle 1917 (EcN): results of a prospective
study of the records of 3,807 patients.
Z Gastroenterol.
2006;
44
651-656
- 74
Kruis W, Weinzierl M, Schussler P. et al .
Comparison of the therapeutic effect of wheat bran, mebeverine and placebo in patients
with the irritable bowel syndrome.
Digestion.
1986;
34
196-201
- 75
Kumar A, Kumar N, Vij J C. et al .
Optimum dosage of ispaghula husk in patients with irritable bowel syndrome: correlation
of symptom relief with whole gut transit time and stool weight.
Gut.
1987;
28
150-155
- 76
Kurdi P, Tanaka H, van Veen H W. et al .
Cholic acid accumulation and its diminution by short-chain fatty acids in Bifidobacteria.
Microbiology.
2003;
149
2031-2037
- 77
Ladas S D, Grammenos I, Tassios P S. et al .
Coincidental malabsorption of lactose, fructose, and sorbitol ingested at low doses
is not common in normal adults.
Dig Dis Sci.
2000;
45
2357-2362
- 78
Lawal A, Kern M, Sidhu H. et al .
Novel evidence for hypersensitivity of visceral sensory neural circuity in irritable
bowel syndrome patients.
Gastroenterology.
2006;
130
26-33
- 79 Layer P, Keller J. Das Reizdarmsyndrom - Pathogenese, Diagnostik und Therapie. Bremen;
Uni-Med Verlag 2003: 75
- 80
Lea R, Whorwell P J.
The Role of Food Intolerance in Irritable Bowel Syndrome.
Gastroenterol Clin N Am.
2005;
34
247-255
- 81
Ledochowski M, Widner B, Fuchs D.
Fruktoseunverträglichkeit.
J Ernährungsmed.
2000;
3
10-14
- 82
Ledochowski M, Murr C, Lass-Florl C. et al .
Increased serum amylase and lipase in fructose malabsorbers.
Clin Chim Acta.
2001;
311
119-123
- 83
Lin H C.
Small intestinal bacterial overgrowth: A frame-work for understanding irritable bowel
disease.
JAMA.
2004;
292
852-858
- 84
Locke G R, Zinsmeister A R, Talley N J. et al .
Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities.
Am J Gastroenterol.
2000;
95
157-165
- 85
Longstreth G F, Fox D D, Youkeles L. et al .
Psyllium therapy in the irritable bowel syndrome: a double blind trial.
Ann Intern Med.
1981;
95
53-56
- 86
Longstreth G F, Thompson W G, Chey W D. et al .
Functional bowel disorders.
Gastroenterology.
2006;
130
1480-1491
- 87
Lucey M R, Clark M L, Lowndes J O. et al .
Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled
crossover study.
Gut.
1987;
28
221-225
- 88
Madisch A, Heydenreich C J, Wieland V. et al .
Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination
preparation as compared to cisapride. A multicenter, reference-controlled double-blind
equivalence study.
Drug Res.
1999;
49
925-932
- 89
Madsen J L, Linnet J, Rumessen J J.
Effect of nonabsorbed amounts of a fructose-sorbitol mixture on small intestinal transit
in healthy volunteers.
Dig Dis Sci.
2006;
51
147-153
- 90
Majamaa H, Isolauri E.
Probiotics: a novel approach in the management of food allergy.
J Allergy Clin Immunol.
1997;
99
179-185
- 91
Malinen E, Rinttila T, Kajander K. et al .
Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy
controls with real-time PCR.
Am J Gastroenterol.
2005;
100
373-382
- 92
Manning A P, Harvey R F, Heaton K W.
Wheat fiber and irritable bowel syndrome: a controlled trial.
Lancet.
1977;
1
419-421
- 93
Marks J, Carvou N J, Debnam E S. et al .
Diabetes increases facilitative glucose uptake and GLUT2 expression at the rat proximale
tubule brush border membrane.
J Physiol.
2003;
553
137-145
- 94
Matthews S B, Waud J P, Roberts A G. et al .
Systemic lactose intolerance: a new perspective on an old problem.
Postgrad Med J.
2005;
81
167-173
- 95
May B, Kuntz H D, Kieser M. et al .
Efficacy of a fixed peppermint oil and caraway oil on gastruduodenal motility.
Phytother Res.
1996;
14
20-23
- 96
May B, Köhler S, Schneider B.
Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil
in patients suffering from functional dyspepsia.
Aliment Pharmacol Ther.
2000;
14
1671-1677
- 97
Micklefield G, Greving I, May B.
Effects of peppermint oil and caraway oil on gastrointestinal motility.
Phytother Res.
2000;
14
20-23
- 98
Mishkin D, Sablauskas L, Yalovsky M. et al .
Fructose and sorbitol malabsorption in ambulatory patients with functional dyspepsia:
comparison with lactose maldigestion/malabsorption.
Dig Dis Sci.
1997;
42
2591-2598
- 99
Mönnikes H, Schmidtmann M, Voort. et al .
Arzneimitteltherapie des Reizdarmsyndroms.
Internist.
2006;
47
1073-1083
- 100
Molin C.
Probiotics in foods not containing milk or millk constituents, with special reference
to Lactobacillus plantarum 299v.
Am J Clin Nutr.
2001;
73
380S-385S
- 101
Monsbakken K W, Vandvik P O, Farup P G.
Perceived food intolerance in subjects with irritable bowel syndrome - etiology, prevalence
and consequences.
Eur J Clin Nutr.
2006;
60
667-672
- 102
Müller P, Meier C, Böhme H J. et al .
Fructose breath hydrogen test - is it really a harmless diagnostic procedure?.
Dig Dis.
2003;
21
276-278
- 103
Nelis G F, Vermeeren M A, Jansen W.
Role of fructose-sorbitol malabsorption in the irritable bowel syndrome.
Gastroenterology.
1990;
99
1016-1020
- 104
Newcomer A D, McGill D B.
Irritable bowel syndrome. Role of lactase deficiency.
Mayo Clin Proc.
1983;
58
339-341
- 105
Niec A M, Frankum B, Talley N J.
Are adverse food reactions linked to irritable bowel syndrome?.
Am J Gastroenterol.
1998;
93
2184-2190
- 106
Niedzielin K, Kordecki H, Birkenfeld B.
A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum
299V in patients with irritable bowel syndrome.
Eur J Gastroenterol Hepatol.
2001;
13
1143-1147
- 107
Nigam P, Kapoor K K, Rastog C K. et al .
Different therapeutic regimens in irritable bowel syndrome.
J Assoc Physicians India.
1984;
12
1041-1044
- 108
Niv E, Naftali T, Hallak R. et al .
The efficacy of Lactobacillus reuteri ATCC 55 730 in the treatment of patients with
irritable bowel syndrome - a double blind, placebo-controlled, randomized study.
Clin Nutr.
2005;
24
925-931
- 109
Nobaek S, Johansson M L, Molin G. et al .
Alteration of intestinal microflora is associated with reduction in abdominal bloating
and pain in patients with irritable bowel syndrome.
Am J Gastroenterol.
2000;
95
1231-1238
- 110
Nucera G, Gabrielli M, Lupascu A. et al .
: Abnormal breath test to lactose, fructose and sorbitol in irritable bowel sindrome
may be explained by small intestinal bacterial overgrowth.
Aliment Pharmacol Ther.
2005;
21
1391-1395
- 111
O’Mahony L, McCarthy J, Kelly P. et al .
Lactobacilli and bifidobacterium in irritable bowel syndrome: symptom responses and
relationship to cytokine profiles.
Gastroenterology.
2005;
128
541-551
- 112
O’Sullivan M A, O’Morain C A.
Bacterial supplementation in the irritable bowel syndrome: a randomized double-blind
placebo-controlled crossover study.
Dig Liver Dis.
2000;
32
294-301
- 113
Park M I, Camilleri M.
Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia?
A systematic review.
Neurogastroenterol Motil.
2006;
18
595-607
- 114
Parker T J, Woolner J T, Prevost A T. et al .
Irritable bowel syndrome: is the search for lactose intolerance justified?.
Eur J Gastroenterol Hepatol.
2001;
13
219-225
- 115
Parisi G, Bottona E, Carrara M. et al .
Treatment effects of partially hydrolyzed guar gum on symptoms and qualità of life
of patients with irritable bowel sindrome: a multicenter randomized open trial.
Dig Dis Sci.
2005;
50
1107-1112
- 116
Parisi G C, Zilli M, Miani M P. et al .
High-fiber diet supplementation in patients with irritable bowel sindrome (IBS): a
multicenter, randomized, open trial comparison between wheat bran diet and partially
hydrolyzed guar gum (PHGG).
Dig Dis Sci.
2002;
47
1697-1704
- 117
Petitpierre M, Gumovski P, Girard J P.
Irritable bowel syndrome and hypersensitivity to food.
Ann Allergy.
1985;
54
538-540
- 118
Prior A, Whorwell P J.
Double blind study of ispaghula in irritable bowel syndrome.
Gut.
1987;
28
1510-1513
- 119
Quartero A O, Meineche-Schmidt V, Muris J. et al .
Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable
bowel syndrome.
The Cochrane Database of Systematic Reviews.
2005;
Issue 2. Art. No.: CD 003 460
DOI: 0.1002 / 14 651858.CD 003 460.pub2
- 120
Quigley E.
The use of probiotics in functional bowel disease.
Gastroenterol Clin N Ann.
2005;
34
533-545
- 121
Ravich W J, Bayless T M, Thomas M.
Fructose. Incomplete intestinal absorption in humans.
Gastroenterology.
1983;
84
26-29
- 122
Ritchi J A, Truelove S C.
Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide and ispaghula
husk.
BMJ.
1979;
1
376-378
- 123
Ritchi J A, Truelove S C.
Comparison of various treatments for irritable bowel syndrome.
BMJ.
1980;
281
1317-1319
- 124
Riordan S M, Kim R.
Bacterial overgrowth as a cause of irritable bowel syndrome.
Curr Opin Gastroenterol.
2006;
22
669-673
- 125
Roberfroid M B, Delzenne N M.
Dietary fructans.
Annu Rev Nutr.
1998;
18
117-143
- 126
Romagnuolo J, Schiller D, Baily R J.
Using breath tests wisely in a gastroenterology practice: An evidence-based review
of indications and pitfalls in interpretation.
Am J Gastroenterol.
2002;
97
1113-1126
- 127
Rumessen J J, Gudmand-Hoyer E.
Absorption capacity of fructose in healthy adults. Comparison with sucrose and its
constituent monosaccharides.
Gut.
1986;
27
1161-1168
- 128
Rumessen J J, Gudmand-Hoyer E.
Malabsorption of fructose-sorbitol mixtures. Interactions causing abdominal distress.
Scand J Gastroenterol.
1987;
22
431-436
- 129
Rumessen J J, Gudmand-Hoyer E.
Functional bowel disease: Malabsorption and abdominal distress after ingestion of
fructose, sorbitol, and fructose-sorbitol mixtures.
Gastroenterology.
1988;
95
694-700
- 130
Rumessen J J.
Fructose and related food carbohydrates. Source, intake, absorption, and clinical
implications.
Scand J Gastroenterol.
1992;
27
819-828
- 131
Saggioro A.
Probiotics in the treatment of irritable bowel syndrome.
J Clin Gastroenterol.
2004;
38 (Suppl)
S104-106. Erratum in: J Clin Gastroenterol 2005; 39: 261
- 132
Saito Y A, Locke G R, Weaver A L. et al .
Diet and functional gastrointestinal disorders: a population-based case-control study.
Am J Gastroenterol.
2005;
100
2743-2748
- 133
Sanders D S, Carter M J, Hurlstone D P. et al .
Association of adult coeliac disease with irritable bowel syndrome: a case-control
study in patients fulfilling ROME II criteria referred to secondary care.
Lancet.
2001;
358
1504-1508
- 134
Schultz M, Linde H J, Lehn N. et al .
Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain
GG in healthy volunteers.
J Dairy Res.
2003;
70
165-173
- 135
Sen S, Mullan M M, Parker T J. et al .
: Effect of Lactobacillus plantarum 299v on colonic fermentation and symptoms of irritable
bowel syndrome.
Dig Dis Sci.
2002;
47
2615-2620
- 136
Shahbazkhani B, Forootan M, Merat S. et al .
Coeliac disease presenting with symptoms of irritable bowel syndrome.
Aliment Pharmacol Ther.
2003;
18
231-235
- 137
Shepherd E J, Helliwell P A, Mace O J. et al .
Stress and glucocorticoid inhibit apical GLUT2-trafficking and intestinal glucose
absorption in rat small intestine.
J Physiol.
2004;
560
281-290
- 138
Shepherd S J, Gibson P R.
Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective
dietary management.
J Am Diet Assoc.
2006;
106
1631-1639
- 139
Simren M, Mansson A, Langkilde A M. et al .
Food-related gastrointestinal symptoms in the irritable bowel syndrome.
Digestion.
2001;
63
108-115
- 140
Skoog S M, Bharucha A E.
Dietary fructose and gastrointestinal symptoms: a review.
Am J Gastroenterol.
2004;
99
2046-2050
- 141
Snook J, Shepherd H A.
Bran supplementation in the treatment of irritable bowel syndrome.
Aliment Pharmacol Ther.
1994;
8
511-514
- 142
Soltoft J, Gudman-Hoyer E, Krag B. et al .
A double blind trial of the effect of wheat bran on symptoms of irritable bowel syndrome.
Lancet.
1976;
2
270-272
- 143 Stein J, Jordan A. Ernährung bei Krankheiten des Gastrointestinaltraktes. Stein
J, Jauch KW Praxishandbuch klinische Ernährung und Infusionstherapie Springer-Verlag
Berlin, Heidelberg, New York 2003: 582-626
- 144
Summers R W, Johlin F C.
Fructose intolerance is due to rapid orocecal transit and not small bowel bacterial
overgrowth.
Gastroenterology.
2001;
120
A1369 (Abstract)
- 145
Symons P, Jones M P, Kellow J E.
Symptom provocation in irritable bowel syndrome. Effects of differing doses of fructose-sorbitol.
Scand J Gastroenterol.
1992;
27
940-944
- 146
Terjung B, Lammert F.
Laktoseintoleranz: Neue Aspekte eines alten Problems.
Dtsch Med Wochenschr.
2007;
132
271-275
- 147
Thiesen A, Wild G E, Keelan M. et al .
Locally and systemically active glucocorticosteroids modify intestinal absorption
of sugars in rats.
J Appl Physiol.
2003;
94
583-590
- 148
Tolliver B A, Jackson M S, Jackson K L. et al .
Does lactose maldigestion really play a role in the irritable bowel?.
J Clin Gastroenterol.
1996;
23
15-17
- 149
Torii A, Toda G.
Management of Irritable Bowel Syndrome.
Int Med.
2004;
43
353-359
- 150
Toskes P P, Connery K L, Ritchey T W.
Calcium oplycarbophil compared with placebo in the irritable bowel syndrome.
Aliment Pharmacol Ther.
1993;
7
87-92
- 151
Truswell A S, Seach J M, Thorburn A W.
Incomplete absorption of pure fructose in healthy subjects and the facilitating effect
of glucose.
Am J Clin Nutr.
1988;
48
1424-1430
- 152
Vanderhoof J A, Young R J.
Use of prebiotics in childhood gastrointestinal disorders.
J Pediatr Gastroenterol Nutr.
1998;
27
323-332
- 153
Verdu E F, Collins S M.
Irritable bowel syndrome and probiotics: from rationale to clinical use.
Curr Opin Gastroenterol.
2005;
21
697-701
- 154
Vernia P, Marinaro V, Argnani F. et al .
Self-reported milk intolerance in irritable bowel syndrome: what should we believe?.
Clin Nutr.
2004;
23
996-1000
- 155
Vesa T H, Seppo L M, Marteau P R. et al .
Role of irritable bowel syndrome in subjective lactose intolerance.
Am J Clin Nutr.
1998;
67
71 071-71 075
- 156
Villagrasa M, Boix J, Humbert P. et al .
Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the
treatment of irritable bowel syndrome.
Ital J Gastroenterol.
1991;
23 (Suppl)
67-70
- 157
Wahnschaffe U, Ullrich R, Riecken E O. et al .
Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome.
Gastroenterology.
2001;
121
1329-1338
- 158
Walker J, Jijon H B, Diaz H. et al .
5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose
transport: a possible role for AMPK.
Biochem J.
2005;
385
485-491
- 159
Zar S, Kumar D, Benson M J.
Food hypersensitivity and irritable bowel syndrome.
Aliment Pharmacol Ther.
2001;
15
439-449
- 160
Zar S, Benson M J, Kumar D.
Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel
syndrome.
Am J Gastroenterol.
2005;
100
1550-1557
- 161
Zuckerman M J.
The role of fiber in the treatment of irritable bowel syndrome.
J Clin Gastroenterol.
2006;
40
104-108
Prof. Jürgen M. Stein
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