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DOI: 10.1055/s-2007-963435
© Karl Demeter Verlag im Georg Thieme Verlag KG Stuttgart · New York
Cost-Saving Analysis of Screening Colonoscopy in Germany[*]
Kosten-Nutzen-Analyse der präventiven Koloskopie in DeutschlandPublication History
manuscript received: 24.6.2007
manuscript accepted: 16.7.2007
Publication Date:
17 September 2007 (online)

Zusammenfassung
Einleitung: Die präventive Koloskopie wurde 2002 in das Nationale Früherkennungsprogramm in Deutschland eingeführt. Wir berechneten Kosten und Einsparungen der Screening- und Nachsorge-Koloskopien, um herauszufinden, ob die Einsparungen die Kosten des Screeningmodells kompensieren. Methoden: Die Studie ist eine Modellkalkulation basierend auf einer großen Online-Dokumentation der Vorsorge-Koloskopie. Die Kosten und möglichen Einsparungen der präventiven Koloskopie wurden über einen definierten Zeitraum von 10 Jahren ausgewertet. Die Basisdaten über Befunde, Komplikationen und Kosten der präventiven Koloskopie wurden einer großen Online-Dokumentation mit 109 989 Untersuchungen und der aktuellen Bezahlung präventiver Punktwerte in der ambulanten Medizin in Deutschland entnommen. Plausible Basisparameter über die Charakteristika der Screening- und Nachsorge-Koloskopie, der Adenom-Karzinom-Progression, des Wiederauftretens von Adenomen und der Kosten für Diagnose und Behandlung von kolorektalen Karzinomen wurden den verfügbaren Datenquellen entnommen. Der Einfluss der wichtigsten Annahmen in dem Modell wurde durch Sensitivitätsanalyse ausgewertet. Ergebnisse: Ein Programm, das auf einer einmaligen Screening-Koloskopie beruht, kann in Deutschland in einem Zeitraum von 10 Jahren zu Netto-Einsparungen führen, die durch eine Vermeidung von Darmkrebs-Behandlungskosten zustande kommen, die die gesamten Screening-, Nachsorge- und Komplikationskosten kompensieren. Die durchschnittlichen Einsparungen pro Koloskopie liegen zwischen 121 € und 623 €, wobei in unserem Modell verschiedene Progressions- und Rekurrenzraten von Adenomen und Karzinomen und Karzinomkosten zwischen 21 820 € und 40 000 € angenommen wurden. Schlussfolgerungen: Die Analyse der empirisch erhobenen Daten aus einem deutschlandweiten Screening-Koloskopie-Programm zeigt Netto-Einsparungen durch die Prävention kolorektaler Karzinome, die die gesamten Kosten von Screening und Nachsorge kompensieren. Limitationen des Modells ergeben sich aus der Tatsache, dass die Annahmen für einzelne Modellparameter aus der Literatur entnommen werden mussten.
Abstract
Background: Screening colonoscopy was introduced into the National Cancer Prevention Program in Germany in 2002. We have explored costs and savings of screening and surveillance colonoscopy to investigate whether the induced savings may compensate for the costs of screening. Methods: The study design was a model calculation based on data of a large-scale documentation of screening colonoscopy. The costs and savings of screening colonoscopy were evaluated over a defined period of 10 years. Basic data about findings, adverse effects and costs of screening colonoscopy were obtained from a large-scale online registry of 109 989 procedures and from the actual payments of procedures in Germany. Plausible baseline parameter values of the characteristics of screening and surveillance colonoscopy, of adenoma progression and recurrence, and of costs for diagnosis and treatment of colorectal cancer were based on available data. The impact of major model assumptions was evaluated by sensitivity analyses. Results: A programme based on one-time screening colonoscopy could result in net savings over a period of 10 years in Germany due to avoidance of cancer treatment costs compensating for the costs of screening, surveillance and adverse effects. Average net savings from € 121 to € 623 per screenee could be achieved according to our model assuming different progression and recurrence rates of adenomas and carcinoma costs from € 21 820 to € 40 000. Limitations: For some major model parameters assumptions had to be derived from the literature. Conclusions: This analysis based on empirical data from the nationwide screening colonoscopy programme in Germany suggests net savings resulting from colorectal cancer prevention that compensate for the costs of screening and surveillance.
Schlüsselwörter
kolorektales Karzinom - Adenom - Kosten-Nutzen-Analyse - Prävention - Screening - Koloskopie
Key words
colorectal cancer - Adenoma - cost-saving analysis - prevention - screening - colonoscopy
1 Part of the results has been presented as oral presentation at the German Cancer Congress 2006 in Berlin and as poster at the DDW 2006 in Los Angeles.
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1 Part of the results has been presented as oral presentation at the German Cancer Congress 2006 in Berlin and as poster at the DDW 2006 in Los Angeles.
Prof. Dr. Andreas Sieg
Praxis für Gastroenterologie
Römerstr. 7
69115 Heidelberg
Germany
Phone: ++ 49/62 21/6 59 99 31
Fax: ++ 49/62 21/6 59 99 33
Email: dr.andreas.sieg@t-online.de