Z Gastroenterol 2008; 46: 20-22
DOI: 10.1055/s-2007-963481

© Georg Thieme Verlag KG Stuttgart · New York

Efficacy, Effectiveness and Cost-Effectiveness of Endoscopic Screening Methods

H. Brenner1
  • 1Div. of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Further Information

Publication History

Publication Date:
26 March 2008 (online)


Epidemiological evidence suggests that incidence of colorectal cancer can be reduced by 60 - 90 % among participants of preventive colonoscopy with removal of precancerous lesions. Even with sigmoidosopy, the majority of cancers can be prevented. Cost-effectiveness analyses suggest screening schemes based on colonoscopy every 10 years or on sigmoidoscopy every 5 years to be highly cost effective compared to other preventive measures. Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence.


H. Brenner

Div. of Clinical Epidemiology and Aging Research, German Cancer Research Center

Bergheimer Straße 20

69115 Heidelberg, Germany

Phone: ++ 49/62 21/54 81 40

Fax: ++ 49/62 21/54 81 42

Email: H.Brenner@dkfz.de