Z Gastroenterol 2008; 46: 20-22
DOI: 10.1055/s-2007-963481

© Georg Thieme Verlag KG Stuttgart · New York

Efficacy, Effectiveness and Cost-Effectiveness of Endoscopic Screening Methods

H. Brenner1
  • 1Div. of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Further Information

Publication History

Publication Date:
26 March 2008 (online)


Epidemiological evidence suggests that incidence of colorectal cancer can be reduced by 60 - 90 % among participants of preventive colonoscopy with removal of precancerous lesions. Even with sigmoidosopy, the majority of cancers can be prevented. Cost-effectiveness analyses suggest screening schemes based on colonoscopy every 10 years or on sigmoidoscopy every 5 years to be highly cost effective compared to other preventive measures. Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence.


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H. Brenner

Div. of Clinical Epidemiology and Aging Research, German Cancer Research Center

Bergheimer Straße 20

69115 Heidelberg, Germany

Phone: ++ 49/62 21/54 81 40

Fax: ++ 49/62 21/54 81 42

Email: H.Brenner@dkfz.de