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Int J Sports Med 2007; 28(11): 909-915
DOI: 10.1055/s-2007-964966
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Effect of NSAID on Muscle Injury and Oxidative Stress

S. McAnulty1 , L. McAnulty2 , D. Nieman1 , J. Morrow3 , C. Dumke1 , D. Henson4
  • 1Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC, USA
  • 2Family and Consumer Sciences, Appalachian State University, Boone, NC, USA
  • 3Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
  • 4Department of Biology, Appalachian State University, Boone, NC, USA
Further Information

Publication History

accepted after revision October 10, 2006

Publication Date:
31 May 2007 (online)

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Abstract

Indirect markers of muscle damage and delayed onset muscle soreness were examined and correlated to changes in oxidative stress, plasma antioxidant potential, and use or nonuse of non-steroidal anti-inflammatory drugs in 60 ultra-marathoners following the Western States Endurance Run. Blood was collected prior to and immediately following the race and analyzed for muscle damage by creatine phosphokinase and oxidative stress by F2-isoprostanes, protein carbonyls, and lipid hydroperoxides and antioxidant potential by the ferric reducing ability of plasma. Subjects recorded delayed onset muscle soreness during the week following the race. Lipid hydroperoxide concentrations were unchanged, but F2-isoprostanes, protein carbonyls, ferric reducing ability of plasma, creatine phosphokinase, and delayed onset muscle soreness increased significantly postrace. Protein carbonyls were significantly higher postrace in nonsteroidal anti-inflammatory drug users versus nonusers (p < 0.05). However, there was no difference between users and non-users for all other markers. Postrace creatine phosphokinase concentrations were not correlated with oxidative stress markers but were correlated with changes in delayed onset muscle soreness. Based upon these findings, caution should be used when consuming nonsteroidal anti-inflammatory drugs during ultra distance events.

Key words

exercise - drugs - antioxidant potential - lipid oxidation - protein oxidation

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PhD Steven McAnulty

Health, Leisure, and Exercise Science
Appalachian State University

111 Rivers Street

Boone, NC 28608

USA

Phone: + 82 82 62 71 51

Fax: + 82 82 62 31 38

Email: mcanltysr@appstate.edu

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