Abstract
Composite tissue allotransplantation (CTA) is emerging as a potential treatment for
complex tissue defects. A major drawback for CTA remains the requirement of lifelong
immunosuppression. Up to date numerous experimental CTA models have been introduced
to the transplantation literature. After the first hand transplantation in 1998, the
clinical applicability of CTA has attracted a lot of attention. This article will
outline the historical background of CTA and our experience in different CTA models.
Zusammenfassung
Die Allotransplantation von unterschiedlichen Gewebekomponenten in einem Transplantat
(composite tissue allotransplantation, CTA) ist eine sich neu entwickelnde Behandlungsmöglichkeit
für komplexe Gewebedefekte. Die Hauptproblematik liegt unverändert in der Notwendigkeit
einer lebenslangen Immunosuppression. Eine Vielzahl experimenteller Modelle der CTA
wurde bislang publiziert. Nach der ersten allogenen Handtransplantation im Jahre 1998
hat gerade die klinische Anwendung ein großes wissenschaftliches und öffentliches
Interesse erfahren. Diese Übersichtsarbeit soll die historische Entwicklung der Allotransplantation
von Mehrkomponenten-Transplantaten und unsere eigenen Erfahrungen mit verschiedenen
experimentellen Modellen zusammenfassen.
Key words
experimental transplantation - experimental surgery - composite tissue allotransplantation
- CTA
Schlüsselwörter
Transplantation - experimentelle Chirurgie - Mehrkomponenten‐Transplantate - CTA
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M.D., Ph.D., D.Sc. Maria Siemionow
Plastic Surgery/Microsurgery
Cleveland Clinic
9500 Euclid Avenue
Cleveland, OH 44195
USA
Email: siemiom@hotmail.com
