Int J Sports Med 2008; 29(4): 294-299
DOI: 10.1055/s-2007-965352
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

PC-1 Genotype and IRS Response to Exercise Training

S. Park1 , T. Han1 , T. Son1 , H.-S. Kang1
  • 1School of Sport Science, Sungkyunkwan University, Suwon, Republic of Korea
Further Information

Publication History

accepted after revision March 24, 2007

Publication Date:
13 September 2007 (online)


The purpose of this study was to investigate whether the efficacy of exercise training as a means of insulin resistance syndrome (IRS) treatment is dependent on the PC-1 gene K121Q variants. A population of 84 abdominally obese Korean women was analyzed prospectively. Before and after a 12-week exercise (walking) training program, indices of body fatness including body mass index, percent body fat, and waist circumference, and cardiorespiratory fitness were measured. Total cholesterol (TC), triacylglycerol, high-density lipoprotein cholesterol (HDLC), glucose, and insulin were measured in fasting venous blood. At baseline, KK individuals had significantly lower waist circumference (p = 0.019) and TC (p = 0.001) than KQ/QQ individuals did. In particular, compared with KQ/QQ individuals, KK individuals had significantly greater reductions in body weight (p = 0.002), BMI (p = 0.032), and fasting insulin (p = 0.042), and a greater increase in HDLC (p = <0.001), following the 12-week walking exercise program. This study suggests that the PC-1 gene K121Q polymorphism may modulate responses of IRS to exercise training, at least in this population.


Prof. PhD Hyun-Sik Kang

School of Sport Science
Sungkyunkwan University

300 Cheoncheon-dong, Jangan-gu

440-746 Suwon

Republic of Korea

Phone: + 82 3 12 99 69 11

Fax: + 82 3 12 99 69 29

Email: [email protected]