Das ACE-Hemmer-induzierte Angioödem

Zusammenfassung

Bei einem ACE-Hemmer-induzierten Angioödem handelt es sich um eine nichtallergische Medikamentennebenwirkung. Hierfür wird der hohe, wahrscheinlich auf einer Abbaustörung beruhende Bradykininspiegel im Plasma verantwortlich gemacht, der die erhöhte vaskuläre Permeabilität auslöst. ACE-Hemmer-induzierte Angioödeme entwickeln sich rasch und kommen in der Kopf-Hals-Region vor allem im Bereich der Lippe, der Zunge und des Kehlkopfes vor. Neue Therapieansätze könnten in naher Zukunft erstmals eine kausale Behandlung des ACE-Hemmer-induzierten Angioödems ermöglichen.

Abstract

ACE-inhibitor induced angioedema is a non-allergic drug-related side effect. Inhibited bradykinin degradation leads to an unphysiological enhanced bradykinin plasma level with vascular leakage and, consequently, to angioedema. ACE-inhibitor induced angioedema develop rapidly in the head and neck region. Typical sites of manifestation are lips, tongue, and larynx. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future.

Schlüsselwörter

Angioödem - ACE-Hemmer - Bradykinin - Icatibant - Larynxödem

Key words

angioedema - ACE-inhibitor - bradykinin - laryngeal edema

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