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Semin Thromb Hemost 2007; 33(2): 179-184
DOI: 10.1055/s-2007-969032
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Platelet Glycoprotein VI: A Novel Marker for Acute Coronary Syndrome

Boris Bigalke1 , Harald Langer1 , Tobias Geisler1 , Stephan Lindemann1 , Meinrad Gawaz1
  • 1Medizinische Klinik III, Eberhard Karls-Universität Tübingen, Tübingen, Germany
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Publication History

Publication Date:
06 March 2007 (online)

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ABSTRACT

The platelet collagen receptor glycoprotein (GP) VI is critical for the formation of arterial thrombosis. GPVI platelet surface expression was examined in patients with stable angina and in patients with acute coronary syndrome (ACS). Surface expression of platelet activation markers such as P-selectin, GPIbα, and platelet GPVI was determined by flow cytometry. Patients with ACS showed a significantly enhanced GPVI expression compared with patients with stable angina and healthy controls. The expression of GPVI correlated well with CD62P. Elevated platelet GPVI expression was associated with ACS independent of markers of myocardial necrosis such as troponin and creatine kinase. In ACS, platelet surface GPVI expression was already elevated several hours before troponin and creatine kinase indicated myocardial injury. We conclude that the determination of the platelet-specific thrombotic marker GPVI may help to identify patients at risk before myocardial ischemia is evident.

KEYWORDS

Platelets - glycoprotein (GP) VI - collagen - acute coronary syndrome

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Stephan LindemannM.D. 

Medizinische Klinik III, Eberhard Karls Universität Tübingen

Otfried-Müller-Str. 10, D-72076 Tübingen, Germany

Email: stephan.lindemann@med.uni-tuebingen.de

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