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Neuropediatrics 1999; 30(3): 111-119
DOI: 10.1055/s-2007-973474
Review Articles

© Hippokrates Verlag GmbH Stuttgart

Neurofibromatosis Type 1: The Role of Neuroradiology

W. Mukonoweshuro1 , P. D. Griffiths1 , Susan Blaser2
  • 1Academic Department of Radiology, University of Sheffield, Sheffield, UK,
  • 2Departments of Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
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Publication History

Publication Date:
12 March 2007 (online)

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Abstract

Neurofibromatosis type 1 is the commonest of the phakomatoses with a prevalence of 1 in 3-4000. In common with most of the other phakomatoses it is a genetic disorder with typical dermatological manifestations. Many organ systems can be affected but brain, spine, cranial nerve and peripheral nerve involvement is frequent. In this review we will describe the central nervous system manifestations of neurofibromatosis type 1 and discuss some of the controversies raised by investigating children with this disorder.

Key words

Neurofibromatosis type 1 - Magnetic resonance - Paediatric tumour - Optic glioma