Abstract
Two cases of spontaneous improvement of optic pathway lesions in neurofibromatosis
type 1 are reported. At time of diagnosis the children were aged 21 and 32 months
respectively; they have been followed by both MRI and clinical evaluation for 5 and
4 years. MRI findings of the first 19 months of follow-up for Case 1 have been described
by us before. On MRI serial evaluation, Case 1 showed an almost complete normalization
of the size of lesions and a resolution of enhancement, whereas Case 2 showed a slight
decrease in the size of lesions and a resolution of enhancement. From the clinical
point of view Case 1 showed a normalization of his clinical signs, whereas in Case
2, a visual improvement was only slight, if at all present. In Case 1, the clinical
improvement seemed to follow the spontaneous regression of the lesions detected by
MRI.
Key words
Neurofibromatosis 1 - Optic pathway glioma - Optic glioma - MRI
