Neuropediatrics, Inhaltsverzeichnis Neuropediatrics 1998; 29(6): 320-321DOI: 10.1055/s-2007-973585 Short communications © Hippokrates Verlag GmbH StuttgartInfantile Spasms Associated with a Histamine H1 AntagonistA. Yasuhara1 , A. Ochi2 , Y. Harada2 , Y. Kobayashi2 1Department of Pediatrics, Kansai Medical University Kori Hospital, Neyagawa, Osaka, and 2Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka, Japan Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract Some anti-allergic agents act as histamine H1 antagonists and induce seizure discharges in epileptic patients. Of these agents, ketotifen has an especially potent effect. We have experienced 2 cases of 4-month-old boys who developed infantile spasms 8 to 10 days after ketotifen administration. They showed almost the same clinical course with regard to their age, the interval between ketotifen administration and the onset of seizures, their symptoms and EEG abnormalities. These cases suggest that the administration of ketotifen to young infants may be hazardous with regard to inducing infantile spasms. Key words Infantile spasms - Histamine H1 antagonist - Ketotifen - Seizure - Infant PDF (290 kb)