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Horm Metab Res 2007; 39(5): 377-383
DOI: 10.1055/s-2007-976542
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Plasma Adiponectin is Increased in Mice Selectively Bred for High Wheel-running Activity, but not by Wheel Running per sé

L. M. Vaanholt 1 , P. Meerlo 2 , T. Garland 3  Jr. , G. H. Visser 1 , 4 , G. van Dijk 5
  • 1University of Groningen, Department of Behavioural Biology, Haren, The Netherlands
  • 2University of Groningen, Molecular Neurobiology, Haren, The Netherlands
  • 3University of California, Riverside, Department of Biology, Riverside, USA
  • 4Centre for Isotope Research, Nijenborgh 4, Groningen, The Netherlands
  • 5University of Groningen, Neuroendocrinology, Haren, The Netherlands
Further Information

Publication History

received 4. 9. 2006

accepted 22. 12. 2006

Publication Date:
29 May 2007 (online)

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Abstract

Mice selectively bred for high wheel-running activity (S) have decreased fat content compared to mice from randomly bred control (C) lines. We explored whether this difference was associated with alterations in levels of circulating hormones involved in regulation of food intake and energy balance, and whether alterations were caused by the presence of a running wheel. Plasma levels of leptin, adiponectin, and corticosterone as well as body composition were analyzed in male S mice housed with (+) and without (-) access to running wheels at ages of 10 and 18 months. These levels were compared to those found in C+ mice. Plasma corticosterone did not differ among groups. While plasma leptin levels tended to be lower in S+ mice as compared to S- or C+ mice, these differences were largely attributable to differences in fat content. Adiponectin levels were increased in S mice (+60%) compared to C mice, irrespective of wheel access. High levels of this hormone may be a trait co-segregated in mice bred for high wheel-running activity.

Key words

corticosterone - exercise - experimental evolution - leptin - metabolic rate - selective breeding

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Correspondence

L. M. Vaanholt

Kerklaan 30

9751 NN Haren

The Netherlands

Phone: +31/50/363 20 51

Fax: +31/50/363 52 05

Email: l.m.vaanholt@rug.nl

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