Horm Metab Res 2000; 32(4): 121-124
DOI: 10.1055/s-2007-978604
Originals Basic

© Georg Thieme Verlag Stuttgart · New York

Coexistence of Intestinal Trefoil Factor (hITF) and Oxytocin in Magnocellular Neurons in the Human Hypothalamus

T. Griepentrog1 , M. Bauer2 , C. Hornstein2 , H. Sauer3 , G. F. Jirikowski1
  • 1Institut für Anatomie, Anatomie II, Friedrich-Schiller-Universität Jena, Germany
  • 2Department of Neuropathology, Psychiatrisches Krankenhaus Wiesloch, Germany
  • 3Department of Psychiatry, Friedrich-Schiller-Universität Jena, Germany
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19. April 2007 (online)

Human intestinal trefoil factor hITF, a polypeptide of the Pdomain family, was found to occur in hypothalamic neurons. With combined immunofluorescence and immunoperoxidase technique we investigated the coexistence of hITF with the neurohypophysial peptide oxytocin and the associated neurophysin I in sections of the human hypothalamus. In the supraoptic nucleus, 39.2% of magnocellular oxytocinergic perikarya show hITF immunoreactivity. A similar distribution was observed in perivascular hypothalamic oxytocinergic neurons, whereas in the paraventricular nucleus, 99% of the oxytocinergic neurons show hITF coexpression. In the periventricular nucleus (PEV), single, scattered neurons with both immunoreactivities occur. Our findings indicate that hITF and oxytocin are coexpressed in a portion of the magnocellular neurons in the human hypothalamus, and that hITF is among the neurohypophysial peptides.