Horm Metab Res 2000; 32(4): 139-141
DOI: 10.1055/s-2007-978608
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

An Anti-Insulin Serum, But Not a Glucagon Antagonist, Alters Glycemia in Fed Chickens

J. Simon1 , M. Derouet1 , C. Gespach2
  • 1Station de Recherches Avicoles, NRA, Nouzilly, France
  • 2INSERM Unité 482: Signalisation et Fonctions Cellulaires, Application au Diabète et aux Cancers Digestifs, Hôpital Saint Antoine, Paris, France
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Publication History



Publication Date:
19 April 2007 (online)

Attempts at altering plasma glucose and, as a consequence, food intake were performed in fed broiler chickens by single iv injection of des-His1(Glu9) glucagon amide (a glucagon antagonist) or a non-stimulating anti-insulin serum. Plasma glucose level was not altered by des-His1(Glu9) glucagon amide but was rapidly and largely increased (for at least 2 h) by the injection of the insulin-immune serum. Hour and cumulative food intake were unaltered up to 10 h post injection. These results strongly suggest that in fed chickens, plasma glucose is mainly, if not exclusively, controlled by plasma insulin, and that the transient and heavy hyperglycemia evoked by inhibiting insulin action does not alter food intake.