Horm Metab Res 1999; 31(5): 335-339
DOI: 10.1055/s-2007-978749
Symposium Reports

© Georg Thieme Verlag Stuttgart · New York

Neurotransmitter Transporters: Target for Endocrine Regulation

D. P. Figlewicz1 , 3 , T. A. Patterson5 , A. Zavosh1 , M. D. Brot1 , M. Roitman1 , P. Szot2 , 4
  • 1Dept. of Psychology, University of Washington, Seattle, WA, USA
  • 2Dept. of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
  • 3Dept. of Metabolism/Endocrinology, VA Puget Sound Health Care System, Seattle, WA, USA
  • 4Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA
  • 5Pfizer Central Research, Groton, CT 06340, USA
Further Information

Publication History



Publication Date:
20 April 2007 (online)

Aminergic signaling in the CNS is terminated by clearance from the synapse via high-affinity transporter molecules in the presynaptic membrane. Relatively recent sequence identification of these molecules has now permitted the initiation of studies of regulation of transporter function at the cellular and systems levels. In vitro studies provide evidence that the transporters for dopamine, serotonin, and γ-aminobutyric acid are substrates for regulation by protein kinase C signaling. In vivo studies provide evidence that insulin and adrenal and gonadal steroid hormones may regulate the synthesis and activity of the transporters. Future directions should permit evaluation of the role of endocrine regulation in neurotransmitter clearance, and thus in the maintenance of normal CNS aminergic signaling.