The microsomal glucose-6-phosphatase enzyme is situated with its active site inside
the lumen of the endoplasmic reticulum and for normal enzyme activity in vivo, transport systems are needed for the substrates and products of the enzyme. Most
studies of glucose-6-phosphatase have been carried out on the liver enzyme and relatively
little is known about the regulation of the kidney glucose-6-phosphatase enzyme system.
Here we demonstrate that the liver and kidney glucose-6-phosphatase systems are regulated
differently by dexamethasone and that dexamethasone acts on both the glucose-6-phosphatase
enzyme and T1 its associated glucose-6-phosphate transport protein.
Glucose-6-Phosphatase - Microsome - Liver - Kidney - Glucocorticoid
