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© Georg Thieme Verlag Stuttgart · New York
Effect of Surgically Induced Hypoestrinism on Immunoregulation in Perimenopausal Women
23 April 2007 (online)
The object of the present study was to investigate the effect of bilateral oophorectomy (OOX) on CD4+ and CD8+ subsets of T-lymphocytes in 8 immunologically healthy perimenopausal women with regular bleeding. Between the 12th and 16th week after OOX, CD8+ (%) increased in all of the investigated women (mean values compared to values before OOX: 37.8 ± 3.4 vs 26 ± 4.13, p < 0.05). CD4+ increased in five women, and decreased in another three (means: 36.4 ± 3.6 vs 38 ± 4.6). The immunoregulatory index (CD4+/CD8+ ratio) declined in seven women, while it was unchanged in one (means: 1.09 ± 0.2 vs 1.71 ± 0.22, p < 0.05). The compliance of the treatment was controlled by serum estrogen, LH and FSH. From these results it is apparent that surgically induced hypoestrinism inhibits immunoregulation in perimenopausal women.
T-cell - CD4+/CD8+ - Estrogen - Oophorectomy