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© Georg Thieme Verlag Stuttgart · New York
The Diabetic BB Rat Neither Th1 nor Th2?
23 April 2007 (online)
A long term objective of our work has been to identify and characterize the T cells responsible for causing autoimmune type I diabetes in the spontaneously diabetic BB rat. Based on the Th1/Th2 paradigm encompassing “regulated” and “regulatory” T cells, our analyses show that there are very few “regulatory” peripheral Th2 cells. The “regulated” T cells that remain express an unusual, immature phenotype that is neither Th1 nor Th2. Our data also indicate that transcript expression for p561ck, an enzyme required for T cell development, is abnormal in BB peripheral T cells. We discuss the role abnormal transcript expression of p561ck might play in retarding the development of mature regulatory Th2 cells while simultaneously influencing the escape of autoreactive T cells from the thymus.
BB Rat - Autoimmunity - p561ck - Th1/Th2