Horm Metab Res 1996; 28(9): 426-429
DOI: 10.1055/s-2007-979831

© Georg Thieme Verlag Stuttgart · New York

Clinical Evaluation of Glimepiride versus Glyburide in NIDDM in a Double-Blind Comparative Study

Diana G. Dills1 , Jill Schneider2 , The Glimepiride/Glyburide Research Group
  • 1Department of Medicine, Section of Endocrinology, University of Wisconsin, Madison, Wisconsin, U.S.A.
  • 2Hoechst Marion Roussel Pharmaceuticals Inc., Clinical Research, Bridgewater, New Jersey, U.S.A.
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Publication History

Publication Date:
23 April 2007 (online)


We report on the results of a one-year, multicenter, randomized, double-blind, parallel-group titration study of the new sulfonylurea agent, glimepiride, versus use of non-micronized glyburide to treat 577 patients with non-insulin dependent diabetes mellitus (NIDDM). Similar decreases in both fasting plasma glucose and HbA1C were found using glimepiride and glyburide. There was a lower incidence of hypoglycemia with glimepiride than glyburide.