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DOI: 10.1055/s-2007-985867
© Georg Thieme Verlag KG Stuttgart · New York
Visfatin: A Putative Biomarker for Metabolic Syndrome is not Influenced by Pioglitazone or Simvastatin Treatment in Nondiabetic Patients at Cardiovascular Risk - Results from the PIOSTAT Study
Publikationsverlauf
received 29. 03. 2007
accepted 10. 07. 2007
Publikationsdatum:
22. Oktober 2007 (online)
Abstract
Objective: The aim of the study was to analyze the effect of pioglitazone (PIO) and simvastatin (SIMVA) on adiponectin and visfatin concentrations in nondiabetic patients with metabolic syndrome and increased risk for cardiovascular complications in a prospective randomized clinical trial.
Research Design and Methods: One-hundred twenty-five nondiabetic patients with increased cardiovascular risk [78 females, 47 males, age (mean±STD:58.6±7.8years, BMI:30.8±4.2(kg/m2] were included after randomization to PIO+lacebo, SIMVA+placebo, or PIO+SIMVA treatment for 3 months. At baseline and endpoint, measurements of HbA1c, glucose, insulin, LDL cholesterol, adiponectin and visfatin were performed. Insulin resistance was assessed by means of the HOMAIR-score.
Results: Improvement in the HOMAIR-score was observed with PIO and the combination, but not with SIMVA alone, which was accompanied by an increase in adiponectin with PIO treatment groups, but a decrease with SIMVA alone (baseline/endpoint: PIO: 14.0±8.2 mg/l/ 27.6± 14.5 mg/l, p<0.05; PIO+SIMVA: 11.7±10.0 mg/l/26.7±15.7 mg/l, p<0.05; SIMVA: 15.5±12.7 mg/l/ 11.6±7.0 mg/l, p<0.05). No change could be observed in the visfatin concentrations (PIO: 47.6±14.5 ng/ml/48.0±11.6 ng/ml, PIO+SIMVA: 45.1±10.9 ng/ml/47.9±10.1 ng/ml, SIMVA: 49.2± 13.4 ng/ml/52.1±16.7 ng/ml, n. s. in all cases).
Conclusions: Insulin resistance and/or cardiovascular risk indicators were not associated with visfatin levels. Regulation of visfatin secretion occurs through biochemical pathways independent from those influenced by pioglitazone or simvastatin.
Key words
adiponectin - metabolic syndrome - pioglitazone - simvastatin - visfatin
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Correspondence
A. PfütznerMD,PhD
Professor of Applied Clinical Research
Institute for Clinical Research and Development
Parcusstrasse 8
55116 Mainz
Germany
Telefon: +49/6131/576 36 13
Fax: +49/6131/576 36 11
eMail: andreasp@ikfe.de