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DOI: 10.1055/s-2007-990282
© Georg Thieme Verlag KG Stuttgart · New York
Urinary Epidermal and Insulin-Like Growth Factor Excretion in Autistic Children
Publication History
received 20. 02. 2007
accepted 23. 08. 2007
Publication Date:
05 November 2007 (online)
Abstract
Growth factors have been implicated in the pathogenesis of autism. We have investigated daily urinary excretion of insulin-like growth factor-1 (IGF-1), epidermal growth factor, and insulin-like growth factor binding protein-3 in autistic children (n=34, age 2-5 years) and age-matched control children (n=29). The mean urinary IGF-1 level was lower in the autism group than the control group (p=0.03). Height was normal. These findings suggest altered IGF-1 metabolism in young autistic children. The cause-effect relationship should be examined by longitudinal studies and insulin-like growth factor provocation tests.
Key words
autism - growth factor - pathogenesis - insulin-like growth factor - IGF-1
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Correspondence
B. Anlar
Division of Pediatric Neurology
Department of Pediatrics
Faculty of Medicine
Hacettepe University
06100 Ankara
Turkey
Phone: +90/312/305 11 65
Fax: +90/312/438 16 71
Email: banlar@hacettepe.edu.tr