Urinary Epidermal and Insulin-Like Growth Factor Excretion in Autistic Children

Abstract

Growth factors have been implicated in the pathogenesis of autism. We have investigated daily urinary excretion of insulin-like growth factor-1 (IGF-1), epidermal growth factor, and insulin-like growth factor binding protein-3 in autistic children (n=34, age 2-5 years) and age-matched control children (n=29). The mean urinary IGF-1 level was lower in the autism group than the control group (p=0.03). Height was normal. These findings suggest altered IGF-1 metabolism in young autistic children. The cause-effect relationship should be examined by longitudinal studies and insulin-like growth factor provocation tests.

Key words

autism - growth factor - pathogenesis - insulin-like growth factor - IGF-1

References

• 1 Anlar B, Sullivan KA, Feldman EL. Insulin-like growth factor-I and central nervous system development.  Horm Metab Res. 1999;  31 120-125
• 2 Aylward EH, Minshew NJ, Field K, Sparks BF, Singh N. Effects of age on brain volume and head circumference in autism.  Neurology. 2002;  9 176-183
• 3 Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD. et al . Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study.  Neurology. 2001;  57 245-254
• 4 Fall CH, Clark PM, Hindmarsh PC, Clayton PE, Shiell AW, Law CM. Urinary GH and IGF-I excretion in nine year-old children: relation to sex, current size and size at birth.  Clin Endocrinol. 2000;  53 69-76
• 5 Harum KH, Alemi L, Johnston MV. Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.  Neurology. 2001;  56 207-214
• 6 Kato M, Mizuguchi M, Sakuta R, Takashima S. Hypertrophy of the cerebral white matter in hemimegalencephaly.  Pediatr Neurol. 1996;  14 335-338
• 7 Katoda H. Height and weight of Tokyo school children with and without intellectual handicaps.  Ann Hum Biol. 1991;  18 327-339
• 8 Limoges E, Mottron L, Bolduc C, Berthiaume C, Godbout R. Atypical sleep architecture and the autism phenotype.  Brain. 2005;  128 1049-1061
• 9 Miyazaki K, Narita N, Sakuta R, Miyahara T, Naruse H, Okado N. et al . Serum neurotrophin concentrations in autism and mental retardation: a pilot study.  Brain Dev. 2004;  26 292-295
• 10 Sucuoglu B, Oktem F, Akkok F, Gokler B. Otistik çocukların degerlendirilmesinde kullanılan ölçeklere iliskin bir çalısma.  3P Dergisi. 1996;  4 6-12 , [Eng Abstr]
• 11 Vanhala R, Turpeinen U, Riikonen R. Low levels of insulin-like growth factor-I in cerebrospinal fluid in children with autism.  Dev Med Child Neurol. 2001;  43 614-616
• 12 Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism.  Ann Neurol. 2005;  57 67-81
• 13 Yalaz K, Epir S. Physical growth measurements of preschool urban Turkish children.  Turk J Pediatr. 1983;  25 155-165

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