Skull Base 2008; 18(1): 053-058
DOI: 10.1055/s-2007-993048
CASE REPORT

© Thieme Medical Publishers

Novel Multidisciplinary Approach for Treatment of Langerhans Cell Histiocytosis of the Skull Base

Mandy J. Binning1 , Douglas L. Brockmeyer1
  • 1Department of Neurosurgery, University of Utah, Salt Lake City, Utah
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Publication History

Publication Date:
06 November 2007 (online)

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ABSTRACT

Langerhans cell histiocytosis frequently manifests as lesions of the skull. The disease can present with a wide spectrum of forms, from an isolated eosinophilic granuloma to multiple lesions with diffuse systemic involvement. The authors report the case of a 12-year-old boy with a 1-month history of left temporal and periorbital pain and headaches. Noncontrast computed tomography of the head was done at the time of initial presentation and was interpreted as normal. Over the next month, the patient continued to have headaches and periorbital swelling and began having bloody discharge from his nose. Magnetic resonance imaging of the brain ordered by his pediatrician showed a lesion in the left infratemporal fossa, left orbit, and sphenoid bone. The lesion was biopsied and confirmed to be Langerhans cell histiocytosis. We describe a novel multidisciplinary approach for treatment of this tumor.

REFERENCES

Douglas L BrockmeyerM.D. 

Department of Neurosurgery, Primary Children's Medical Center, University of Utah

100 N. Medical Drive, Salt Lake City, UT 84113

Email: douglas.brockmeyer@hsc.utah.edu