Semin Thromb Hemost 1999; 25(3): 265-272
DOI: 10.1055/s-2007-994930
Copyright © 1999 by Thieme Medical Publishers, Inc.

Protein C and S Deficiency

Frank A. Nizzi JR. , Harold S. Kaplan
  • University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Further Information

Publication History

Publication Date:
06 February 2008 (online)


Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization. The classification of the deficiency states is dependent upon determination of the quantity and functional activity of either protein.