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DOI: 10.1055/s-2007-996230
Somatomedin Activity in Sera of Genetically Small Mice
Publication History
1979
1979
Publication Date:
22 April 2008 (online)
Summary
Somatomedin activity as determined by the stimulation of [3H]thymidine incorporation into chick embryo fibroblast DNA, was measured in extracts of sera from genetically small mice. Somatomedin activity was low in the sera from growth hormone deficient mice [Snell (dw/dw), Ames (df/df), and little (lit/lit)] whereas Somatomedin activity was normal in serum from the pygmy (pg/pg) mouse, a mutant proposed as a model for growth hormone resistance. GH treatment of the Snell mouse resulted in an increase in somatomedin activity to normal levels.
Key-words
Snell (dw/dw), Ames (df/df), little (lit/lit), pygmy (pg/pg) somatomedin activity - chick embryo fibroblasts - growth hormone