Horm Metab Res 1980; 12(7): 334-338
DOI: 10.1055/s-2007-996283

© Georg Thieme Verlag, Stuttgart · New York

Characterization of the β-Adrenergic Receptor Mediating Secretion of Parathyroid Hormone

S. C. Kukreja, G. A. Ayala, P. Banerjee, E. N. Bowser, G. K. Hargis, G. A. Williams
  • Section of Endocrinology, Departments of Medicine and Nuclear Medicine, VA West Side Medical Center and University of Illinois College of Medicine, Chicago, Illinois, U.S.A.
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Publication Date:
14 March 2008 (online)


In vitro incubation studies with bovine parathyroid gland slices compared the relative responsiveness of parathyroid hormone (PTH) secretion to isoproterenol, epinephrine or norepinephrine. Isoproterenol was the most potent and norepinephrine the least potent of the three stimuli, suggesting a β2 type of an adrenergic response. However in this in vitro system, tazalol, a selective β1 adrenergic agonist significantly stimulated PTH secretion, whereas terbutaline, a selective β2 agonist had no effect. In addition, practolol, a selective β1 adrenergic antagonist blocked isoproterenol- or tazolol-stimulated PTH secretion. In vivo studies in normal human subjects showed that injection of the nonselective β agonist, isoproterenol, (0.15 mg s.c.) significantly increased, whereas injection of the selective β2 agonist, terbulatine (0.3 mg s.c.) had no effect on serum PTH levels. These latter studies with putative selective β adrenergic agents suggest that the β adrenergic receptor mediating PTH secretion is of the β1 type (in contrast to the studies above with nonselective agents). The studies suggest that the β adrenergic receptor mediating PTH secretion apparently differs from the classical β1 receptor described in the myocardium or the classical β2 receptor described in the bronchial smooth muscle.