Horm Metab Res 1980; 12(8): 361-363
DOI: 10.1055/s-2007-996293
© Georg Thieme Verlag, Stuttgart · New York

Human Pancreatic Polypeptide: Studies in Fasting and in the Growth Hormone Deficient State

Shirley W. Loo, K. H. Gabbay, T. J. Merimee1
  • Harvard Medical School and Children's Hospital Medical Center, Boston, Massachusetts, U.S.A.
  • 1University of Florida College of Medicine, Department of Medicine, Gainesville, Florida, U.S.A.
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Publication Date:
22 April 2008 (online)


Human pancreatic polypeptide (hPP) was measured in eight normal subjects and six growth hormone deficient dwarfs after insulin-induced hypoglycemia. hPP concentrations increased similarly in both groups with induction of hypoglycemia. In eight normal subjects fasted for 72 hours, no significant elevation of hPP occurred. This is contrary to a previous report indicating such a relationship. Despite the rationale that hPP might play a role in the metabolism of fasting and that its secretion might be altered by growth hormone, no evidence for these relationships could be documented in man.