Semin Thromb Hemost 1999; 25(1): 117-121
DOI: 10.1055/s-2007-996434
Copyright © 1999 by Thieme Medical Publishers, Inc.

Dimensions of Quality of Life and Self-Monitoring Therapy with Oral Anticoagulants-Still Research or Everyday Practice?

Thomas Wenzel* , Stefan Mörsdorf , Ingrid Sibitz* , Joachim F. Schenck , Hemma Griengl* , Wolfhardt Erdlenbruch , Walter Heinrich* , Boris Krischek, Peter Birner, Job Harenberg§
  • From the *Division of Social Psychiatry and Psychiatric Epidemiology, University Hospital for Psychiatry, Vienna, Austria,
  • †Department of Clinical Hemostaseology and Transfusion Medicine, University Clinics, Homburg- Saar, Germany,
  • ‡Department of Neurology, Division of Neurological Rehabilitation, University Hospital for Psychiatry, Vienna, Austria, and
  • §Ist Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany.
Further Information

Publication History

Publication Date:
06 February 2008 (online)


In correlation with increased life expectancy of patients, quality of life (QOL) has become a factor of increasing interest by the patient himself and also of importance in health-care planning and recruitment of financial resources. In this context, self-monitoring of long-term anticoagulant treatment might be a strategy that could mean a step forward in health-related as well as general life satisfaction for patients participating in self-monitoring programs. Also, the new strategy of increased homecontrol of anticoagulant treatment illustrates the complexity of multiple factors that can lead to changes in the subjective feeling and objective aspects of QOL. Our intention in a pilot study was to probe the feasibility of QOL research and relevant factors of influence by retrospectively evaluating data from two groups of outpatients seen in a large treatment center. The high frequency (n = 8 in sample 2) of disturbed sleep as a simple screening indicator stresses the probable importance of undetected depression, which might require treatment and could confound research as to QOL. Instruments to measure QOL in oral anticoagulation self-monitoring should therefore be adapted to the heterogeneous structure of factors in the target population, and include psychological parameters, especially in regard to health-related locus of control and mood.