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Horm Metab Res 1980; 12(9): 439-443
DOI: 10.1055/s-2007-999169
© Georg Thieme Verlag, Stuttgart · New York

The Effect of Somatostatin (SRIF) on the Release of Amino Acids from Skeletal Muscle

C. Magno-Sumbilla, R. M. Collins, Jr., P. T. Ozand
  • Department of Pediatrics, University of Maryland School of Medicine and Walter P. Carter Center Research Laboratories, Baltimore, Maryland, U.S.A.
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Publication History

1979

1979

Publication Date:
24 April 2008 (online)

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Summary

1. Somatostatin (SRIF, somatotropin release inhibiting factor), at a concentration of 2 × 10-8M (32 ng/ml) decreased the rate of alanine release (˜ 45 %) and increased glutamine release (˜ 30 %) in in vitro preparations of m. extensor digitorum longus (EDL) muscle from 35-40 day old Wistar rats. These effects of SRIF were observed under both aerobic and anaerobic conditions.

2. SRIF increased the formation of 14CO2 from alanine but not from glutamine, glutamate, leucine, isoleucine or valine.

3. The incorporation of alanine, glutamine, glutamate, leucine, isoleucine and valine into muscle protein was unaffected by the presence of SRIF.

Key-Words

Somatostatin - Amino Acid Release - Rat Skeletal Muscle