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Horm Metab Res 1980; 12(10): 494-496
DOI: 10.1055/s-2007-999185
© Georg Thieme Verlag, Stuttgart · New York

Effects of Neuraminidase Treatment on Solubilized Insulin Receptor

M. Kasuga, O. Ezaki, Y. Akanuma, K. Kosaka
  • Third Department of Internal Medicine Faculty of Medicine, University of Tokyo, Hongo, Tokyo, Japan
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Publication History

1980

1980

Publication Date:
14 March 2008 (online)

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Summary

Neuraminidase treatment of triton-solubilized insulin receptors from rat fat cell membranes caused release of sialic acid and changed the isoelectric point (pI) of the insulin receptor from 4.7 to 5.6. Neuraminidase had no effect on the number or affinity of insulin receptors. These results indicate that the insulin receptor contains sialic acid, but that this sialic acid is not involved in the binding reaction.

Key-Words

Neuraminidase - Solubilized Insulin Receptor - Isoelectric Point