Horm Metab Res 1980; 12(11): 601-604
DOI: 10.1055/s-2007-999209
© Georg Thieme Verlag, Stuttgart · New York

Comparative Studies of the Antilipolytic Effect of Insulin and Adenosine in the Perifused Isolated Fat Cell

S. S. Solomon, B. P. Turpin, W. C. Duckworth
  • Research Service, Department of Medicine, Veterans Administration Medical Center, and University of Tennessee, Center for the Health Sciences, Memphis, Tennessee, U.S.A.
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Publication Date:
22 April 2008 (online)


Insulin and adenosine are both antilipolytic when studied in the epinephrine-stimulated perifused isolated fat cell. Sub-maximal combinations of insulin plus adenosine are additive but not synergistic. The polypeptide hormone insulin produces an antilipolytic effect which manifests itself as a “lag” in restoration of epinephrine-stimulated lipolysis after removal of the insulin. No such lag is observed with the non-peptide, small molecular weight adenosine. Herein, we demonstrate the antilipolytic effect of two distinct, physiologically important agents in the perifused isolated fat cell.