Comparative Studies of the Antilipolytic Effect of Insulin and Adenosine in the Perifused Isolated Fat Cell
22 April 2008 (online)
Insulin and adenosine are both antilipolytic when studied in the epinephrine-stimulated perifused isolated fat cell. Sub-maximal combinations of insulin plus adenosine are additive but not synergistic. The polypeptide hormone insulin produces an antilipolytic effect which manifests itself as a “lag” in restoration of epinephrine-stimulated lipolysis after removal of the insulin. No such lag is observed with the non-peptide, small molecular weight adenosine. Herein, we demonstrate the antilipolytic effect of two distinct, physiologically important agents in the perifused isolated fat cell.
Adenosine - Insulin - Antilipolysis - Perifused Fat Cell - Hormone Action