Horm Metab Res 1980; 12(11): 621-624
DOI: 10.1055/s-2007-999214
© Georg Thieme Verlag, Stuttgart · New York

Mode of Action of Somatostatin in Inhibiting Parathyroid Hormone Secretion

S. C. Kukreja, G. K. Hargis, E. N. Bowser, G. A. Williams
  • Section of Endocrinology, Departments of Medicine and Nuclear Medicine, VA West Side Medical Center and University of Illinois College of Medicine, Chicago, Illinois, U.S.A.
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Publication Date:
22 April 2008 (online)


Effects of somatostatin on basal and low calcium-, isoproterenol- or dibutryl cyclic AMP (DBcAMP)-stimulated parathyroid hormone (PTH) secretion were evaluated in vitro with bovine parathyroid tissue. Low calcium, isoproterenol or DBcAMP alone significantly stimulated PTH secretion. Somatostatin 1 or 4 μg/ml significantly inhibited these stimulated PTH secretions. Inhibition of isoproterenol-stimulated PTH secretion was more complete than was the inhibition of low calcium- or DBcAMP-stimulated secretion. The studies indicate that somatostatin inhibits PTH secretion by an action distal to cAMP generation. The more complete inhibition of isoproterenol-stimulated PTH secretion suggests that somatostatin may also have additional effects on or proximal to the formation of cyclic AMP.