Int J Sports Med 1987; 08(4): 298-303
DOI: 10.1055/s-2008-1025673
© Georg Thieme Verlag Stuttgart · New York

A Promising Novel Therapy for Achilles Peritendinitis:Double-Blind Comparison of Glycosaminoglycan Polysulfate and High-Dose Indomethacin

H. Sundqvist, B. Forsskåhl, M. Kvist
  • Department of Orthopaedic Surgery, Sabbatberg's Hospital, Stockholm, Sweden
    Sports Medical Research Unit, University of Turku, Finland
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Publication History

Publication Date:
14 March 2008 (online)


In this double-blind trial in 60 recreational athletes suffering from Achilles peritendinitis, we compared the effect of local injections of glycosaminoglycan polysulfate (GAGPS) with oral indomethacin (IM) administered over a 2-week period. Orthotic devices were prescribed in 66% of the cases to control biomechanical errors. The results after 1-year follow-up showed that GAGPS had a good overall therapeutic effect on two-thirds of the patients compared to one-third of the IM treated. In the patients with symptoms lasting longer than 3 months, IM had an effect in only 12% while GAGPS was beneficial in 59%. Twenty-five cases of non-responders and relapses underwent a crossover treatment. Those who received IM in this second period did not benefit from this treatment while those who received GAGPS showed a moderate to good effect in 8/17 (47%) after a 2-week follow-up. A different mode of action is suggested as an explanation of the encouraging results.