Z Gastroenterol 2008; 46(7): 712-724
DOI: 10.1055/s-2008-1027378
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Gastroenterologische Palliativmedizin

Gastroenterological Palliative CareM. H. Holtmann1 , D. Domagk2 , M. Weber3 , M. Moehler1 , G. Pott4 , G. Ramadori5 , W. Domschke2 , P. Galle1
  • 1I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität, Mainz
  • 2Medizinische Klinik und Poliklinik B, Westfälische Wilhelms-Universität, Münster
  • 3Interdisziplinäre Einrichtung für Palliativmedizin und III. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität Mainz
  • 4Medizinische Klinik, Gastroenterologie und Palliativmedizin, Euregioklinik, Marienkrankenhaus Nordhorn
  • 5Abteilung Gastroenterologie, Zentrum Innere Medizin, Georg-August-Universität, Göttingen
Further Information

Publication History

Manuskript eingetroffen: 19.12.2007

Manuskript akzeptiert: 14.3.2008

Publication Date:
10 July 2008 (online)

Zusammenfassung

Die Palliativmedizin gewinnt in Deutschland aus gesellschaftlichen, medizinischen und ökonomischen Gründen zunehmend an Bedeutung. Durch die Gründung der Arbeitsgemeinschaft „Gastroenterologische Palliativmedizin” hat die DGVS 2007 dieser Entwicklung Rechnung getragen. Patienten mit gastrointestinalen Tumoren oder fortgeschrittenen nichtmalignen Lebererkrankungen stellen ein wichtiges Klientel dar. Ca. 80 % aller palliativmedizinischen Patienten haben gastrointestinale Symptome. Endoskopische Verfahren spielen in der Symptomlinderung eine wichtige Rolle. In dem folgenden Beitrag soll eine Standortbestimmung der gastroenterologischen Palliativmedizin versucht werden. Neben einer Begriffsklärung, einem kurzen geschichtlichen Abriss und den aktuellen gesetzlichen Rahmenbedingungen palliativmedizinischer Arbeit soll auf besondere Aspekte von Ethik, Entscheidungsfindung und Forschung in der Palliativmedizin eingegangen werden. Im Zusammenhang mit der aktuellen Datenlage zu palliativen endoskopischen Eingriffen soll deutlich werden, dass die Rolle des Gastroenterologen über die handwerkliche Durchführung dieser Maßnahmen hinausgeht. Er ist wichtiger Partner in der dialogischen Entscheidungsfindung mit dem Patienten und dem interdisziplinären Team. Am Beispiel eines deutschen Universitätsklinikums soll erläutert werden, wie palliativmedizinische Versorgungsstrukturen unter den Rahmenbedingungen einer universitären Akutklinik implementiert werden können.

Abstract

On consideration of current medical and socio-economical factors, palliative care is becoming an increasingly important aspect of modern medicine in Germany. The German Society for Digestive and Metabolic Disorders (DGVS) has taken this into account by founding the working group “Palliative Gastroenterology”. Patients with gastrointestinal malignancies or advanced non-malignant liver disease represent an important group that benefits from palliative care. Approximately 80 % of all palliative care patients suffer from gastrointestinal symptoms and endoscopic procedures performed by gastroenterologists play an important role in relieving symptoms such as obstruction. It is the object of this paper to evaluate the role of gastroenterologists in palliative medicine. It will give a brief definition, a historical review and the current legal background for palliative care in Germany and examine special aspects of ethics, decision making and research. Considering the current evidence on palliative endoscopic procedures this paper wants to establish the role of the gastroenterologist in palliative care far beyond the mere practicalities of endoscopy. The gastroenterologist is a crucial element of the interdisciplinary palliative care team and a partner to the patient in the process of decision-making. Finally, it is demonstrated how palliative care structures can be implemented in the setting of a university acute-care hospital.

Literatur

  • 1 Clark D. From margins to centre: a review of the history of palliative care in cancer.  Lancet Oncol. 2007;  8 (5) 430-438
  • 2 Lichtman S M, Balducci L, Aapro M. Geriatric oncology: a field coming of age.  J Clin Oncol. 2007;  25 (14) 1821-1823
  • 3 Sepulveda C, Marlin A, Yoshida T. et al . Palliative Care: the World Health Organization’s global perspective.  J Pain Symptom Manage. 2002;  24 (2) 91-96
  • 4 Kettler D. Sterben wo und wie? Palliativmedizin – die vierte Dimension in der modernen Gesundheitsversorgung. Göttingen; Universitätsverlag Göttingen 2006
  • 5 WH Organization .National cancer control programmes: policies and managerial guidelines. 2nd ed. Geneva; World Health Organization 2002
  • 6 Meyers F J, Linder J. Simultaneous care: disease treatment and palliative care throughout illness.  J Clin Oncol. 2003;  21 (7) 1412-1415
  • 7 Aulbert E, Nauck F, Radbruch L. Lehrbuch der Palliativmedizin. 2. Auflage. Stuttgart; Schattauer Verlag 2007
  • 8 Junger S, Pestinger M, Elsner F. et al . Criteria for successful multiprofessional cooperation in palliative care teams.  Palliat Med. 2007;  21 (4) 347-354
  • 9 Pott G. Ethik am Lebensende. 1st ed. Stuttgart; Schattauer GmbH 2007
  • 10 Martini C M, Eco U. Woran glaubt, wer nicht glaubt?. München; DTV 1999
  • 11 Gurlt E. Hufeland, Christoph Wilhelm. Leipzig; Duncker & Humblot 1881: 286-296
  • 12 Cassell E J. The nature of suffering and the goals of medicine.  New Engl J Med. 1982;  306 (11) 639-645
  • 13 Brody H. “My story is broken; can you help me fix it?” Medical ethics and the joint construction of narrative.  Lit Med. 1994;  13 (1) 79-92
  • 14 Saunders C M. The challenge of minimal care. Symington T, Carter RL Scientific foundations of oncology London; Heinemann 1976: 673-680
  • 15 Byock I R. The nature of suffering and the nature of opportunity at the end of life.  Clin Geriatr Med. 1996;  12 (2) 237-252
  • 16 Klaschik E, Nauck F. Historische Entwicklung der Palliativmedizin.  Zentralbl Chir. 1998;  123 620
  • 17 Student J C. Das Hospiz-Buch. 4. erweiterte Auflage. Freiburg; Lambertus Verlag 1999
  • 18 www.dgpalliativmedizin.de
  • 19 Müller M, Kern M, Nauck F. et al .Qualifikation hauptamtlicher Mitarbeiter. Curricula für Ärzte, Pflegende, Sozialarbeiter und Seelsorger in Palliativmedizin. Bonn; Pallia Med Verlag 1997
  • 20 www.baek.de
  • 21 Saunders C. ‘Watch with me’.  Nurs Times. 1965;  61 (48) 1615-1617
  • 22 Kaasa S, Hjermstad M J, Loge J H. Methodological and structural challenges in palliative care research: how have we fared in the last decades?.  Palliat Med. 2006;  20 (8) 727-734
  • 23 Jordhoy M S, Fayers P, Saltnes T. et al . A palliative-care intervention and death at home: a cluster randomised trial.  Lancet. 2000;  356 (9233) 888-893
  • 24 Grande G E, Todd C J, Barclay S I. et al . A randomized controlled trial of a hospital at home service for the terminally ill.  Palliat Med. 2000;  14 (5) 375-385
  • 25 Grande G E, Todd C J. Why are trials in palliative care so difficult?.  Palliat Med. 2000;  14 (1) 69-74
  • 26 Ahlner-Elmqvist M, Jordhoy M S, Jannert M. et al . Place of death: hospital-based advanced home care versus conventional care. A prospective study in palliative cancer care.  Palliat Med. 2004;  18 (7) 585-593
  • 27 Hanks G W, Rose N M, Aherne G W. et al . Analgesic effect of morphine tablets.  Lancet. 1981;  1 (8222) 732-733
  • 28 Concato J, Shah N, Horwitz R I. Randomized, controlled trials, observational studies, and the hierarchy of research designs.  N Engl J Med. 2000;  342 (25) 1887-1892
  • 29 Sackett D L, Rosenberg W M, Gray J A. et al . Evidence based medicine: what it is and what it isn’t.  Bmj. 1996;  312 (7023) 71-72
  • 30 Williams D D, Garner J. The case against “the evidence”: a different perspective on evidence-based medicine.  Br J Psychiatry. 2002;  180 8-12
  • 31 Beauchamp T, Childress J. Principles of Biomedical Ethics. 5th edition. Oxford; University Press, Oxford 2001
  • 32 Marckmann G. Prinzipienorientierte Medizinethik im Praxistest. Rauprich O, Steger F Prinzipienethik in der Biomedizin. Moralphilosophie und medizinische Praxis Frankfurt New York; Campus 2005: 398-415
  • 33 Zwischenbericht Patientenverfügungen. Enquete-Kommission Ethik und Recht der Modernen Medizin Bundesdrucksache 2004 15 / 3700
  • 34 Sahm S. Imperfekte Autonomie und die Grenzen des Instrumentes Patientenverfügung.  Zeitschrift für Medizinische Ethik. 2005;  51 265-275
  • 35 Borasio P G, Putz W, Eisenmenger W P. Verbindlichkeit von Patientenverfügungen gestärkt.  Deutsches Ärzteblatt. 2003;  100 13-136
  • 36 Synofzik M. Tube-feeding in advanced dementia. An evidence-based ethical analysis.  Nervenarzt. 2007;  78 (4) 418-428
  • 37 Ripamonti C, Mercadante S. Pathophysiology and management of malignant bowel obstruction. 3rd ed. Oxford; Oxford University Press 2005
  • 38 Ladas S D, Novis B, Triantafyllou K. et al . Ethical issues in endoscopy: patient satisfaction, safety in elderly patients, palliation, and relations with industry. Second European Symposium on Ethics in Gastroenterology and Digestive Endoscopy, Kos, Greece, July 2006.  Endoscopy. 2007;  39 (6) 556-565
  • 39 Sibille A, Lambert R, Souquet J C. et al . Long-term survival after photodynamic therapy for esophageal cancer.  Gastroenterology. 1995;  108 (2) 337-344
  • 40 Barr H, Kendall C, Stone N. Photodynamic therapy for esophageal cancer: a useful and realistic option.  Technol Cancer Res Treat. 2003;  2 (1) 65-76
  • 41 Kozarek R A. Endoscopic palliation of esophageal malignancy.  Endoscopy. 2003;  35 (8) S9-S13
  • 42 Domschke W, Foerster E C, Matek W. et al . Self-expanding mesh stent for esophageal cancer stenosis.  Endoscopy. 1990;  22 (3) 134-136
  • 43 Baron T H. Expandable metal stents for the treatment of cancerous obstruction of the gastrointestinal tract.  N Engl J Med. 2001;  344 (22) 1681-1687
  • 44 Baron T H, Harewood G C. Enteral self-expandable stents.  Gastrointest Endosc. 2003;  58 (3) 421-433
  • 45 Ramirez F C, Dennert B, Zierer S T. et al . Esophageal self-expandable metallic stents – indications, practice, techniques, and complications: results of a national survey.  Gastrointest Endosc. 1997;  45 (5) 360-364
  • 46 Knyrim K, Wagner H J, Bethge N. et al . A controlled trial of an expansile metal stent for palliation of esophageal obstruction due to inoperable cancer.  N Engl J Med. 1993;  329 (18) 1302-1307
  • 47 Neuhaus H, Hoffmann W, Dittler H J. et al . Implantation of self-expanding esophageal metal stents for palliation of malignant dysphagia.  Endoscopy. 1992;  24 (5) 405-410
  • 48 Adam A, Ellul J, Watkinson A F. et al . Palliation of inoperable esophageal carcinoma: a prospective randomized trial of laser therapy and stent placement.  Radiology. 1997;  202 (2) 344-348
  • 49 Dallal H J, Smith G D, Grieve D C. et al . A randomized trial of thermal ablative therapy versus expandable metal stents in the palliative treatment of patients with esophageal carcinoma.  Gastrointest Endosc. 2001;  54 (5) 549-557
  • 50 Siersema P D, Hop W C, Blankenstein van M. et al . A comparison of 3 types of covered metal stents for the palliation of patients with dysphagia caused by esophagogastric carcinoma: a prospective, randomized study.  Gastrointest Endosc. 2001;  54 (2) 145-153
  • 51 Morgan R A, Ellul J P, Denton E R. et al . Malignant esophageal fistulas and perforations: management with plastic-covered metallic endoprostheses.  Radiology. 1997;  204 (2) 527-532
  • 52 Dua K S, Kozarek R, Kim J. et al . Self-expanding metal esophageal stent with anti-reflux mechanism.  Gastrointest Endosc. 2001;  53 (6) 603-613
  • 53 Wenger U, Johnsson E, Arnelo U. et al . An antireflux stent versus conventional stents for palliation of distal esophageal or cardia cancer: a randomized clinical study.  Surg Endosc. 2006;  20 (11) 1675-1680
  • 54 Shim C S, Jung I S, Cheon Y K. et al . Management of malignant stricture of the esophagogastric junction with a newly designed self-expanding metal stent with an antireflux mechanism.  Endoscopy. 2005;  37 (4) 335-339
  • 55 Kinsman K J, DeGregorio B T, Katon R M. et al . Prior radiation and chemotherapy increase the risk of life-threatening complications after insertion of metallic stents for esophagogastric malignancy.  Gastrointest Endosc. 1996;  43 (3) 196-203
  • 56 Dua K S. Stents for palliating malignant dysphagia and fistula: is the paradigm shifting?.  Gastrointest Endosc. 2007;  65 (1) 77-81
  • 57 Isla A M, Worthington T, Kakkar A K. et al . A continuing role for surgical bypass in the palliative treatment of pancreatic carcinoma.  Dig Surg. 2000;  17 (2) 143-146
  • 58 Choi Y B. Laparoscopic gatrojejunostomy for palliation of gastric outlet obstruction in unresectable gastric cancer.  Surg Endosc. 2002;  16 (11) 1620-1626
  • 59 Yim H B, Jacobson B C, Saltzman J R. et al . Clinical outcome of the use of enteral stents for palliation of patients with malignant upper GI obstruction.  Gastrointest Endosc. 2001;  53 (3) 329-332
  • 60 Feretis C, Benakis P, Dimopoulos C. et al . Palliation of malignant gastric outlet obstruction with self-expanding metal stents.  Endoscopy. 1996;  28 (2) 225-228
  • 61 Graber I, Dumas R, Filoche B. et al . The efficacy and safety of duodenal stenting: a prospective multicenter study.  Endoscopy. 2007;  39 (9) 784-787
  • 62 Seo E H, Jung M K, Park M J. et al . Covered expandable nitinol stents for malignant gastroduodenal obstructions.  J Gastroenterol Hepatol. 2007;  Dec 13, epub ahead of print
  • 63 Maetani I, Tada T, Ukita T. et al . Comparison of duodenal stent placement with surgical gastrojejunostomy for palliation in patients with duodenal obstructions caused by pancreaticobiliary malignancies.  Endoscopy. 2004;  36 (1) 73-78
  • 64 Yates M R 3 rd, Morgan D E, Baron T H. Palliation of malignant gastric and small intestinal strictures with self-expandable metal stents.  Endoscopy. 1998;  30 (3) 266-272
  • 65 Schiefke I, Zabel-Langhennig A, Wiedmann M. et al . Self-expandable metallic stents for malignant duodenal obstruction caused by biliary tract cancer.  Gastrointest Endosc. 2003;  58 (2) 213-219
  • 66 Mutignani M, Tringali A, Shah S G. et al . Combined endoscopic stent insertion in malignant biliary and duodenal obstruction.  Endoscopy. 2007;  39 (5) 440-447
  • 67 Maire F, Hammel P, Ponsot P. et al . Long-term outcome of biliary and duodenal stents in palliative treatment of patients with unresectable adenocarcinoma of the head of pancreas.  Am J Gastroenterol. 2006;  101 (4) 735-742
  • 68 Kim J H, Song H Y, Shin J H. et al . Metallic stent placement in the palliative treatment of malignant gastroduodenal obstructions: prospective evaluation of results and factors influencing outcome in 213 patients.  Gastrointest Endosc. 2007;  66 (2) 256-264
  • 69 Law W L, Choi H K, Chu K W. Comparison of stenting with emergency surgery as palliative treatment for obstructing primary left-sided colorectal cancer.  Br J Surg. 2003;  90 (11) 1429-1433
  • 70 Fregonese D, Naspetti R, Ferrer S. et al . Ultraflex precision colonic stent placement as a bridge to surgery in patients with malignant colon obstruction.  Gastrointest Endosc. 2008;  67 (1) 68-73
  • 71 Law W L, Choi H K, Lee Y M. et al . Palliation for advanced malignant colorectal obstruction by self-expanding metallic stents: prospective evaluation of outcomes.  Dis Colon Rectum. 2004;  47 (1) 39-43
  • 72 Baron T H, Rey J F, Spinelli P. Expandable metal stent placement for malignant colorectal obstruction.  Endoscopy. 2002;  34 (10) 823-830
  • 73 Baron T H. Acute colonic obstruction.  Gastrointest Endosc Clin N Am. 2007;  17 (2) 323-339, vi
  • 74 Repici A, Fregonese D, Costamagna G. et al . Ultraflex precision colonic stent placement for palliation of malignant colonic obstruction: a prospective multicenter study.  Gastrointest Endosc. 2007;  66 (5) 920-927
  • 75 Karoui M, Charachon A, Delbaldo C. et al . Stents for palliation of obstructive metastatic colon cancer: impact on management and chemotherapy administration.  Arch Surg. 2007;  142 (7) 619-623; discussion 623
  • 76 Ramadori G, Lindhorst A, Armbrust T. Colorectal tumors with complete obstruction – endoscopic recovery of passage replacing emergency surgery? A report of two cases.  BMC Gastroenterol. 2007;  7 14
  • 77 Baumhoer D, Armbrust T, Ramadori G. Nonsurgical treatment of the primary tumor in four consecutive cases of metastasized colorectal carcinoma.  Endoscopy. 2005;  37 (12) 1232-1236
  • 78 Armbrust T, Sobotta M, Füzesi L. et al . Chemotherapie-induced suppression to adenoma or complete suppression of the primary in patients with stage IV colorectal cancer: report of four cases.  European Journal of Gastroenterology & Hepatology. 2007;  19 (11) 988-994
  • 79 Ballinger A B, McHugh M, Catnach S M. et al . Symptom relief and quality of life after stenting for malignant bile duct obstruction.  Gut. 1994;  35 (4) 467-470
  • 80 Smith A C, Dowsett J F, Russell R C. et al . Randomised trial of endoscopic stenting versus surgical bypass in malignant low bileduct obstruction.  Lancet. 1994;  344 (8938) 1655-1660
  • 81 Speer A G, Cotton P B, Russell R C. et al . Randomised trial of endoscopic versus percutaneous stent insertion in malignant obstructive jaundice.  Lancet. 1987;  2 (8550) 57-62
  • 82 Speer A G, Cotton P B, MacRae K D. Endoscopic management of malignant biliary obstruction: stents of 10 French gauge are preferable to stents of 8 French gauge.  Gastrointest Endosc. 1988;  34 (5) 412-417
  • 83 Davids P H, Groen A K, Rauws E A. et al . Randomised trial of self-expanding metal stents versus polyethylene stents for distal malignant biliary obstruction.  Lancet. 1992;  340 (8834 – 8835) 1488-1492
  • 84 Knyrim K, Wagner H J, Pausch J. et al . A prospective, randomized, controlled trial of metal stents for malignant obstruction of the common bile duct.  Endoscopy. 1993;  25 (3) 207-212
  • 85 Moss A C, Morris E, Mac M athuna P. Palliative biliary stents for obstructing pancreatic carcinoma.  Cochrane Database Syst Rev. 2006 (2);  CD004200
  • 86 Yeoh K G, Zimmerman M J, Cunningham J T. et al . Comparative costs of metal versus plastic biliary stent strategies for malignant obstructive jaundice by decision analysis.  Gastrointest Endosc. 1999;  49 (4 Pt 1) 466-471
  • 87 Ridder M D. Medizin am Lebensende: Sondenernährung steigert nur selten die Lebensqualität.  Deutsches Ärzteblatt. 2008;  105 (9) A449-A451
  • 88 Rabeneck L, McCullough L B, Wray N P. Ethically justified, clinically comprehensive guidelines for percutaneous endoscopic gastrostomy tube placement.  Lancet. 1997;  349 (9050) 496-498
  • 89 Ahronheim J C, Gasner M R. The sloganism of starvation.  Lancet. 1990;  335 (8684) 278-279
  • 90 Lillemoe K D, Cameron J L, Kaufman H S. et al . Chemical splanchnicectomy in patients with unresectable pancreatic cancer. A prospective randomized trial.  Ann Surg. 1993;  217 (5) 447-455; discussion 456 – 457
  • 91 Mercadante S. Celiac plexus block versus analgesics in pancreatic cancer pain.  Pain. 1993;  52 (2) 187-192
  • 92 Wiersema M J, Wiersema L M. Endosonography-guided celiac plexus neurolysis.  Gastrointest Endosc. 1996;  44 (6) 656-662
  • 93 Gress F, Schmitt C, Sherman S. et al . A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain.  Am J Gastroenterol. 1999;  94 (4) 900-905
  • 94 Gress F, Schmitt C, Sherman S. et al . Endoscopic ultrasound-guided celiac plexus block for managing abdominal pain associated with chronic pancreatitis: a prospective single center experience.  Am J Gastroenterol. 2001;  96 (2) 409-416
  • 95 Davies D D. Incidence of major complications of neurolytic coeliac plexus block.  J R Soc Med. 1993;  86 (5) 264-266
  • 96 Wong G Y, Schroeder D R, Carns P E. et al . Effect of neurolytic celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer: a randomized controlled trial.  Jama. 2004;  291 (9) 1092-1099
  • 97 Weiher E. Die Sterbestunde im Krankenhaus – Was können die Professionellen im Umkreis des Todes tun? Beiträge zur Thanatologie, Johannes-Gutenberg-Universität Mainz, Interdisziplinärer Arbeitskreis Thanatologie, Heft 28, 2004. 
  • 98 Hoppe J D. Die Palliativmedizin gehört zum Aufgabenbereich jedes Arztes.  Deutsches Ärzteblatt. 2007;  1004 1373-1376
  • 99 Reyners A K, Peters F T, Minnen van C A. Palliative care: for whom and by whom?.  Lancet Oncol. 2007;  8 (7) 573-574

1 M. I. Tech Co., Ltd., Korea/Vertrieb durch MTW Endoskopie, Wesel.

2 Boston Scientific Medizintechnik GmbH, Ratingen.

Dr. Martin H. Holtmann

I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität Mainz

Langenbeckstraße 1

55131 Mainz

Phone: ++ 49/61 31/17 57 12

Fax: ++ 49/61 31/17 66 21

Email: mholtman@mail.uni-mainz.de

    >