Semin Neurol 1998; 18(2): 237-242
DOI: 10.1055/s-2008-1040876
© 1998 by Thieme Medical Publishers, Inc.

Chronic Fatigue Syndrome: A Review for Clinicians

Robyn K. Goshorn
  • Department of Internal Medicine, Indiana University Hospital, Indianapolis, Indiana
Further Information

Publication History

Publication Date:
19 March 2008 (online)


Syndromes characterized by persistent fatigue, musculoskeletal pain, sleep disturbance, and subjective cognitive impairment have been common problems in clinical practice for decades. The chronic fatigue syndrome case definition was created to standardize the patient population in research studies and to foster a systematic and comprehensive approach to the attempt to define the etiology and pathophysiology of these syndromes. The pathogenesis of chronic fatigue syndrome remains unknown, though it does appear to be associated with subtle neuroendocrine and immunologic abnormalities. Treatment of chronic fatigue syndrome is empirical. Significant palliation is often possible, though treatment success requires skillful practice of the art of medicine.