Interventional Approaches to Acute Venous Thromboembolism

Suresh Vedantham

doi:10.1055/s-2008-1047563

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2008; 29(1): 056-065
DOI: 10.1055/s-2008-1047563

Interventional Approaches to Acute Venous Thromboembolism

Suresh Vedantham¹

¹Interventional Radiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri

Abstract

ABSTRACT

During the last decade, advances in minimally invasive technologies have spurred a renaissance in the aggressive treatment of venous thromboembolism (VTE) using percutaneous techniques. In this article, we outline the relative risks and benefits of endovascular VTE therapies, highlight clinical situations in which the benefits of endovascular treatment are likely to outweigh its risks, and provide an update regarding the specific new modalities that may be applied to VTE. Pharmacomechanical thrombolysis represents the most promising currently available method to treat VTE. However, pending demonstration that it actually improves VTE outcomes in randomized trials with long-term follow-up, a highly individualized approach to patient selection is recommended. At present, highly compromised patients with pulmonary emboli (PE) in whom systemic thrombolytic therapy has failed or is contraindicated are reasonable candidates for catheter-based PE interventions. Adjunctive pharmacomechanical catheter-directed deep venous thrombosis (DVT) thrombolysis is best indicated for the first-line treatment of patients with phlegmasia cerulea dolens, acute inferior vena cava (IVC) occlusion, and acute iliofemoral DVT after careful clinical assessment and a balanced discussion with the patient. It is hoped that multidisciplinary clinical trials with involvement by both interventionalists and pulmonary physicians will validate these techniques in the near future.

KEYWORDS

Deep vein thrombosis - thrombolysis - postthrombotic syndrome - pulmonary embolism - venous thromboembolism - pharmacomechanical

Full Text

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Suresh VedanthamM.D.

Interventional Radiology Section, Mallinckrodt Institute of Radiology

510 S. Kingshighway, Box 8131, St. Louis, MO 63110

Email: vedanthams@mir.wustl.edu