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Neuropediatrics 1987; 18(3): 153-154
DOI: 10.1055/s-2008-1052469
© Georg Thieme Verlag KG Stuttgart · New York

Paralytic Poliomyelitis in Vaccinated Children

Elisabeth  Dussaix1 , G.  Huault2 , P.  Landrieu2 , M.  Tardieu2 , P.  Lebon3 , J. L. Menetrat4 , J.  Celers4
  • 1Laboratoire de Virologie, Hôpital Bicêtre, F-94275 Le Kremlin Bicêtre, France
  • 2Département de Pédiatrie, Hôpital Bicêtre, F-94275 Le Kremlin Bicêtre, France
  • 3Institut National de la Santé et de la Recherche Médicale, Unité 43, Hôpital Saint Vincent de Paul, F-75674 Paris, Cedex 14, France
  • 4Laboratoire National de la Santé, F-75680 Paris, Cedex 14, France
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Publication History

Publication Date:
19 March 2008 (online)

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Abstract

Paralytic poliomyelitis were observed in two healthy children who both had previously received four doses of standard inactivated poliovaccine (IPV). These children, whose immune defenses were normal, failed to respond to IPV. This absence of antibody response might be related to an insufficient antigenicity of inactivated vaccines, justifying the extensive use of the more potent IPV, now produced on continuous cell lines.

Key words

Paralytic poliomyelitis - Poliovirus - Inactivated poliovaccine

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