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Neuropediatrics 1982; 13(1): 10-13
DOI: 10.1055/s-2008-1059589
DOI: 10.1055/s-2008-1059589
Serum Concentrations and Enzyme Induction in Epileptic Children Treated with Phenytoin and Valproate
Further Information
Publication History
Publication Date:
19 March 2008 (online)
Abstract
In a group of 59 epileptic children treated with Phenytoin (PHT) and valproate sodium (VPA), either alone or in combination, the following effects were studied:
(1) the reciprocal effect on the serum levels of the two drugs, and (2) the enzyme-inducing effects of both drugs.
VPA had no effect on PHT levels, but PHT significantly decreased VPA concentrations. PHT enhanced both y-glutamyltranspeptidase activity (y-GT) and D-glucaric acid excretion (GLA); these effects were potentiated by VPA. VPA alone did not affect y-GT, but significantly enhanced GLA.
Key words
Phenytoin - Valproate - Enzyme induction - Epilepsy - Pharmacokinetics