Horm Metab Res 2008; 40(6): 431-433
DOI: 10.1055/s-2008-1062740
Commentary

© Georg Thieme Verlag KG Stuttgart · New York

Insulin Analogues with Increased Mitogenic Potency - Are they Safe?

B. F. Hansen 1
  • 1Diabetes Biology, Novo Nordisk A/S, Måløv, Denmark
Weitere Informationen

Publikationsverlauf

received 11.10.2007

accepted 12.11.2007

Publikationsdatum:
16. April 2008 (online)

Abbreviations

HMEC

Human Mammary Epithelial Cells

IGF1

Insulin-like growth factor-1

IGF1R

Insulin-like growth factor-1 receptor

Insulin Aspart

B28Asp human insulin

Insulin Detemir

B29Lys(ε-tetradecanoyl), desB30 human insulin

Insulin Glargine

A21Gly,B31Arg,B32Arg human insulin

Insulin Glulisine

B3Lys,B29Glu human insulin

Insulin LisPro

B28Lys,B29Pro human insulin

IR

Insulin receptor

References

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  • 2 Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action.  Nat Rev Mol Cell Biol. 2006;  7 85-96
  • 3 Drejer K. The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake.  Diabetes Metab Rev. 1992;  8 259-286
  • 4 Kurtzhals P, Schaffer L, Sorensen A, Kristensen C, Jonassen I, Schmid C. et al . Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.  Diabetes. 2000;  49 999-1005
  • 5 Hansen BF, Danielsen GM, Drejer K, Sorensen AR, Wiberg FC, Klein HH. et al . Sustained signaling from the insulin-receptor after stimulation with insulin analogs exhibiting increased mitogenic potency.  Biochem J. 1996;  315 271-279
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  • 7 Slieker LJ, Brooke GS, Dimarchi RD, Flora DB, Green LK, Hoffmann JA. et al . Modifications in the b10-region and b26-30-region of the b- chain of human insulin alter affinity for the human igf-i-receptor more than for the insulin-receptor.  Diabetologia. 1997;  40 S54-S61
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  • 10 Kuerzel GU, Shukla U, Scholtz HE, Pretorius SG, Wessels DH, Venter C. et al . Biotransformation of insulin glargine after subcutaneous injection in healthy subjects.  Curr Med Res Opin. 2003;  19 34-40
  • 11 Berti L, Kellerer M, Bossenmaier B, Seffer E, Seipke G, Haring HU. The long-acting human insulin analog hoe-901 - characteristics of insulin signaling in comparison to asp(b10) and regular insulin.  Hormone Met. 1998;  30 123-129
  • 12 Bahr M, Kolter T, Seipke G, Eckel J. Growth-promoting and metabolic-activity of the human insulin analog [gly(a21),arg(b31),arg(b32)]insulin (hoe-901) in muscle-cells.  Eur J Pharmacol. 1997;  320 259-265
  • 13 Kohn WD, Micanovic R, Myers SL, Vick AM, Kahl SD, Zhang LS. et al . pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity.  Peptides. 2007;  28 935-948
  • 14 Ciaraldi TP, Carter L, Seipke G, Mudaliar S, Henry RR. Effects of the long-acting insulin analog insulin glargine on cultured human skeletal muscle cells: Comparisons to insulin and IGF-I.  J Clin Endocrinol Metab. 2001;  86 5838-5847

Correspondence

B.F. Hansen

Diabetes Biology

Novo Nordisk A/S

2760 Måløv

Denmark

Telefon: +45/3079/20 07

Fax: +45/4443/45 87

eMail: bfh@novonordisk.com