Zusammenfassung
Anliegen Untersuchung der Zusammenhänge zwischen metabolischem Syndrom (MTS) und Depression.
Methode Medline-Literaturrecherche. Ergebnisse Das MTS begünstigt die Entwicklung depressiver Störungen und umgekehrt. Beide Erkrankungen
sind mit Insulinresistenz, Diabetes mellitus Typ 2, Adipositas und erhöhtem Herzinfarktrisiko
assoziiert. Bewegungsmangel, Überernährung, Adipositas und Stress spielen für die
Genese des MTS und möglicherweise auch für die der Depression eine Rolle. Schlussfolgerungen Körperliche Aktivität wirkt sich positiv auf alle Einzelfaktoren des MTS, besonders
auf die Insulinresistenz, aus. Körperliche Aktivität hat aber auch antidepressive
Effekte. Tierexperimentelle Studien zeigen, dass körperliche Aktivität grundsätzlich
von großer Bedeutung für die Gehirngesundheit sein könnte, wobei besonders auf die
hippokampale Neuroplastizität hinzuweisen ist.
Abstract
Objective Analysis of coherences between metabolic syndrome (MTS) and depression. Methods Literature research in Medline. Results The metabolic syndrome (MTS) is characterized by the coexistence of (abdominal) obesity,
type 2 diabetes, hypertension and dyslipidaemia while insulin resistance is one pathophysiological
key factor. MTS is a risk factor for the development of depressive disorders and vice
versa. MTS (usually) and depression (quite often) are associated with insulin resistance,
type 2 diabetes, obesity and increased risk of myocardial infarction. Environmental
factors like lack of physical exercise, malnutrition and stress may play an important
role in the genesis of both disorders. Conclusions On the one hand, physical activity has positive effects on all elements of MTS, especially
insulin resistance, on the other hand, mild antidepressant effects of physical activity
have been demonstrated. The results of animal experiments refer to the essential relevance
of physical activity concerning „brain health”, specifically with respect to hippocampal
neuroplasticity.
Schlüsselwörter
metabolisches Syndrom - Depression - körperliche Aktivität - Stress
Key words
metabolic syndrome - depression - physical activity - stress
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PD Dr. med. Norbert-Ullrich Neumann
Abt. Allgemeine Psychiatrie und Psychotherapie des BKH Günzburg an der Donau-Ries-Klinik
Neudegger Allee 6
86609 Donauwörth
eMail: norbert.neumann@bkh-guenzburg.de
