Neuropediatrics 1992; 23(4): 212-213
DOI: 10.1055/s-2008-1071344
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Elevated CSF Glutamate in Rett Syndrome

A.  Hamberger1 , Chr.  Gillberg2 , Anita  Palm1 , B.  Hagberg3
  • 1Institute of Neurobiology, University of Göteborg, Sweden
  • 2Department of Child and Adolescent Psychiatry, University of Göteborg, Sweden
  • 3Department of Pediatrics II, University of Göteborg, Sweden
Further Information

Publication History

Publication Date:
19 March 2008 (online)

Abstract

The concentration of free amino acids was measured in the cerebrospinal fluid of four patients with Rett syndrome. The reference material were patients with autistic disorder who had CSF aminoacid levels similar to those reported for healthy children. The concentration of glutamate - but of no other amino acid - was markedly elevated in the CSF of the RS patients.

The results are discussed in the context of excitotoxicity in neurodegenerative disease.

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