Zeitschrift für Phytotherapie 2008; 29(2): 71-74
DOI: 10.1055/s-2008-1077270

© Sonntag Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Schwarzer Holunder: Volkstümliche Anwendungen wissenschaftlich belegt

Cosima Chrubasik, Sigrun Chrubasik
Further Information

Publication History

Publication Date:
18 June 2008 (online)


Der Schwarze Holunder (Sambucus nigra) wird seit dem Mittelalter medizinisch verwendet. Aufgrund unzureichender Dokumentation wurde die Anwendung aber nur für Zubereitungen aus den Blüten bei der überlieferten Indikation »Infektionen der oberen Atemwege« empfohlen, basierend auf der tierexperimentell nachgewiesenen sekretolytischen Wirkung. Inzwischen gibt es aber auch pharmakologische Untersuchungen zur antientzündlichen Wirkung der Blüten und zur antiviralen, bakteriostatischen und antioxidativen Wirkung der Beeren. Mehrere humanpharmakologische Studien haben belegt, dass Anthocyane in geringen Mengen resorbiert und im Urin ausgeschiedenen werden. Doch sind zur Aufklärung des Zusammenhangs zwischen resorbierten Inhaltsstoffen und antioxidativer Wirkung noch weitere Studien erforderlich. Zwei Studien ergaben Hinweise für die Wirksamkeit eines wässrigen Extrakts aus Holunderbeeren bei Influenza. Eine auf Holunder basierende hypokalorische Diät eignete sich als Impuls zur Lebensumstellung, um eine langfristige Gewichtsreduktion zu erzielen. Ob die Kur aufgrund der darin enthaltenen antioxidativ wirksamen Inhaltsstoffe anderen hypokalorischen Diäten überlegen ist, bleibt weiteren Untersuchungen vorbehalten.


Scientific proof of the traditional use of elderberry as a herbal drug

Since the middle ages, elderberry (Sambucus nigra) is used in traditional medicine. Based on inadequate documentation, use of elderberry has only been recommended for upper respiratory tract infections due to its secretolytic effect demonstrated in animal research. In the meantime, pharmacological investigations also revealed an anti-inflammatory action for elder flower and antiviral, antibacterial and antioxidative effects for elder berries. Several human pharmacological studies have shown that small amounts of anthocyanins are absorbed via the gastrointestinal tract and excreted via the urine. However, further studies are required to elucidate the relation between absorbed compounds and antioxidative effects. There is no doubt that an aqueous elderberry extract alleviates influenza complaints. An elder-based hypocaloric diet has been shown to be appropriate as a starter for life-style change in order to achieve long-term weight reduction. If the diet, due to its antioxidative principle, is superior to other hypocaloric diets, remains to be established.


  • 1 Abuja PM, Murkovic M, Pfannhauser W. Antioxidant and prooxidant activities of elderberry (Sambucus nigra) extract in lowdensity lipoprotein oxidation.  J Agric Food Chem. 1998;  46 4091-4096
  • 2 [Anonymous] . Sambucus nigra . In: Hänsel R, Keller K, Rimpler H, Schneider G (Hrsg.) Hagers Handbuch der Pharmazeutischen Praxis. 5. Aufl. New York, Heidelberg; Springer 1984: 579-586
  • 3 [Anonymous] . Sambucus nigra (Elderberry).  Alternative Med Rev. 2005;  10 51-55
  • 4 Barak V, Birkenfeld S, Halperin T, Kalickman I. The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines.  Isr Med Assoc J. 2002;  4(11 Suppl) 919-922
  • 5 Balasingam S, Lamkin R, Safirman D, Mumcuoglu M, Oxford JS. Neutralizing activity of SambucolR against avian NIBRG-14 (H5N1) influenza virus. IV. International Conference on Influenza, Preventing the Pandemic, Bird flu vaccines London; 2006
  • 6 Bitsch I, Janssen M, Netzel M, Strass G, Frank T. Bioavailability of anthocyanidin-3-glycosides following consumption of elderberry extract and blackcurrant juice.  Int J Clin Pharmacol Ther. 2004;  42 293-300
  • 7 Blumenthal M. The Complete German Commission E Monographs. American Botanical Council; Austin, Texas, USA 1998 124
  • 8 Cao G, Prior RL. Anthocyanins are detected in human plasma after oral administration of an elderberry extract.  Clin Chem. 1999;  45 574-576
  • 9 Chatterjee A, Yasmin T, Bagchi D, Stohs SJ. Inhibition of Helicobacter pylori in vitro by various berry extracts, with enhanced susceptibility to clarithromycin.  Mol Cell Biochem. 2004;  265 19-26
  • 10 Chibanguza G, März R, Sterner W. Zur Wirksamkeit und Toxizität eines pflanzlichen Sekretolytikums und seiner Einzeldrogen.  Arzneim.-Forsch./Drug Res. 1984;  34 32-36
  • 11 Chrubasik C, Maier T, Hofmann T, Torda T, et al.. Use of an elder-based hypocaloric diet as a starter for life-style change. Phytother Res 22 2008, in press
  • 12 Crujeiras AB, Parra MD, Rodriguez MC, et al.. A role for fruit content in energy-restricted diets in improving antioxidant status in obese women during weight loss.  Nutrition. 2006;  22 593-599
  • 13 Farombi EO, Hansen M, Ravn-Haren G, Moller P, Dragsted LO. Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats.  Food Chem Toxicol. 2004;  42 1315-1322
  • 14 Finne Nielsen IL, Elbol Rasmussen S, Mortensen A, Ravn-Haren G, et al.. Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.  Mol Nutr Food Res. 2005;  49 301-308
  • 15 Frank J, Kamal-Eldin A, Lundh T, Maatta K, et al.. Effects of dietary anthocyanins on tocopherols and lipids in rats.  J Agric Food Chem. 2002;  50 7226-7230
  • 16 Frank T, Sonntag S, Strass G, Bitsch I, et al.. Urinary pharmacokinetics of cyanidin glycosides in healthy young men following consumption of elderberry juice.  Int J Clin Pharm Res. 2005;  25 47-56
  • 17 Harokopakis E, Albzreh MH, Haase EM, et al.. Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra).  J Periodontol. 2006;  77 271-279
  • 18 Huber R, Nauck M, Ludtke R, Scharnagl H. Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjects.  Forsch Komplementarmed Klass Naturheilkd. 2003;  10 7-10
  • 19 Milbury PE, Cao G, Prior RL, Blumberg J. Bioavailability of elderberry anthocyanins.  Mech Ageing Dev. 2002;  123 997-1006
  • 20 Mülleder U, Murkovic M, Pfannhauser W. Urinary excretion of cyanidin glycosides.  J Biochem Biophys Methods. 2002;  53 61-66
  • 21 Murkovic M, Abuja PM, Bergmann AR, Zirngast A, et al.. Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study.  Eur J Clin Nutr. 2004;  58 244-249
  • 22 Nakajima JI, Tanaka I, Seo S, Yamazaki M, Saito K. LC/PDA/ESI-MS profiling and radical scavenging activity of anthocyanins in various berries.  J Biomed Biotechnol 2004. 2004;  241-247
  • 23 Parra MD, Martinez de Morentin BE, Perez S, et al.. [In vivo study of mitochondrial oxidation in obese patients treated by means of calorie restriction].  Nutr Hosp. 2004;  19 269-276
  • 24 Wu X, Cao G, Prior RL. Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry.  J Nutr. 2002;  132 1865-1871
  • 25 Wu X, Gu L, Prior RL, McKay S. Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity.  J Agric Food Chem. 2004;  52 7846-7856
  • 26 Youdim KA, Martin A, Joseph JA. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress.  Free Radic Biol Med. 2000;  29 51-60
  • 27 Zakay-Rones Z, Varsano N, Zlotnik M, Manor O, et al.. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama.  J Alt Compl Med. 1995;  1 361-369
  • 28 Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections.  J Int Med Res. 2004;  32 132-140

Cosima Chrubasik
Prof. Dr. med. Sigrun Chrubasik

Institut für Rechtsmedizin

Universität Freiburg

Albertstr. 9

79104 Freiburg