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Thromb Haemost 2005; 93(01): 88-91
DOI: 10.1160/TH04-06-0391
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria

David J. Araten
1   Memorial Sloan-Kettering Cancer Center, New York, New York, USA
,
Howard T. Thaler
1   Memorial Sloan-Kettering Cancer Center, New York, New York, USA
,
Lucio Luzzatto
1   Memorial Sloan-Kettering Cancer Center, New York, New York, USA
2   Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
› Author AffiliationsGrant support: This work was supported by the Doris Duke Charitable Foundation Clinical Scientist Development Award, and by NIH grant R01 HL56778–06. This work was also supported in part by grants from Ministero della Sanità, FIRB and Compagnia di San Paolo, Italy
Further Information

Publication History

Received 23 June 2004

Accepted after revision 04 October 2004

Publication Date:
14 December 2017 (online)

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Summary

Paroxysmal Nocturnal Haemoglobinuria (PNH) results in a marked thrombophilic state by unknown mechanisms. Geographic differences in thrombosis incidence in PNH have been observed. We have reviewed 64 patients with “Classic PNH” from a single institution in order to determine the rate of thrombosis in different ethnic groups.When we compared African- Americans (n=11) and Latin-Americans (n=8) with other patients (n= 45), we found that African-American and Latin-American patients are at increased risk [Hazard ratio 3.66 (p=0.005) and 3.52, (p= 0.035) respectively by Cox regression]. Our data also suggest that this difference in the rate of thrombosis has an impact on length of survival.These findings demonstrate that ethnicity is a risk factor for thrombosis in PNH and have implications for decision-making regarding the management of these patients,including the prevention of thrombosis.

Keywords

Paroxysmal Nocturnal Hemoglobinuria (PNH) - ethnicity - thrombosis - hypercoagulable states - deep venous thrombosis
 

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