Antithrombin extends its job

• References

• 1 Senden NHM, Jeunhomme TMA, Heemskerk JWM. et al. Factor Xa induces cytokine production and expression of adhesion molecules in human umbilical vein endothelial cells. J Immunol 1998; 161: 4318-24.
• 2 Camerer E. et al. Tissue factor- and factor Xdependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000; 97: 5255-60.
• 3 Zaman GJR, Conway EM. The elusive factor Xa receptor: failure to detect transcripts that correspond to the published sequence of EPR1. Blood 2000; 96: 145-8.
• 4 Oelschläger C, Römisch J, Staubitz A. et al. Antithrombin III inhibits nuclear factor κB activation in human monocytes and vascular endothelial cells. Blood 2002; 99: 4015-20.
• 5 Uchiba M. et al. Inhibition of the endothelial cell activation by antithrombin in vitro . Thromb Haemost 2004; 92: 1420-7.
• 6 O’Reilly MS. et al. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science 1999; 285: 1926-8.